These parameters are altered in neurodegeneration. Here we overview the ER and mitochondrial Ca 2+ homeostasis, the composition of ER-mitochondrial Ca 2+ transfer machinery and alterations of the ER-mitochondria Ca 2+ transfer in three major neurodegenerative diseases: motor neurone diseases, Parkinson...
handling) 及钠/钙交换功能研究 浦介麟 BoydenPA. 摘要 目的:研究心肌梗塞细胞钙通道、钙运作及钠/钙交换功能变化。 方法:运用膜片钳全细胞记录法测细胞膜钙电流,荧光技术测细胞内钙浓度。 结果:心肌梗塞细胞钙离子密度明显下降(正常细胞:9.8±1.4pA/pF,心肌梗塞细胞:3.7±0.6 ...
Trimetazidine improved Ca^2+ handling in isoprenaline - mediated myocardial injury of rats [ J]. Exp Physiol, 2006,91 (4) :799.Trimetazidine improved Ca2+ handling in isoprenaline-mediated myocardial injury of rats. Meng,D,Feng,L,Chen,XJ. Experimental Physiology . 2006...
To investigate the potential role of the mNCE in Ca 2+ handling, the NCE blocker CGP37157 (CGP) was used. In addition, experiments were conducted to determine the expression levels of the MCU and mNCE in the two mitochondria pools using western blot. Mitochondrial RCI was higher in the ...
Here we analysed intracellular Ca2+ handling in SAN dissected from mice bearing a mutation in RyR2 found in CPVT patients (RyR2R420Q) and compared to wild type littermates (WT). Animals were implanted with Holter telemetry captors. One week after surgery, ECGs were recorded in basal ...
心肌梗塞细胞L型钙通道,钙运作(CA^2+handling)及钠/钙?… 目的:研究心肌梗塞细胞通道、钙运作及钠/钙交换功能变化。方法:运用膜片钳全细胞记录法测细胞膜钙电流,荧光技术测细胞风钙浓度。结果:心肌梗塞细胞钙离子密度明显下降... 浦介麟,Boyd.,PA - 《中国循环杂志》 被引量: 0发表: 1999年 ...
应该是 钙运作就是 钙离子处理 吧
as loss-of-function (Brugada syndrome). Importantly, these changes in Na+channel function are similar to the CaMKII-mediated effects [67] and remodelling in HF [65]. Moreover, hiPSC-CMs carrying the SCN5A N406K mutation also showed impaired intracellular Ca2+handling and Ca2+-dependent arrhythm...
This is supported not only by evidence linking alterations in Ca 2+ homeostasis to the triggering of apoptotic (and in some cases necrotic) cell death, but also by recent data indicating that a key anti-apoptotic protein, Bcl-2, has a direct effect on ER Ca 2+ handling. We will briefly...
Also, the emergence of tools and concepts for targeting the genetic make-up of the myocardium calls for a better understanding of the interplay of cardiomyocyte Ca2+ handling and mechanical loads. The bi-directionality of interactions between Ca2+ handling and mechanics makes it difficult, however,...