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In solution, both lobes are thought to be free to move around the protein hinge. Binding of ATP (or ATP-competitive ligands) engages residues from both lobes and stabilizes the kinase domain in a “closed” conformation around the hinge. We thus used thermal-shift assay to identify a ligand...
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Journals & Books Help Search My accountSign inMaterials Science and Engineering: C Supports open accessArticles & IssuesVolume 102 Pages 1-922 (September 2019) Download full issue Previous vol/issue Next vol/issue Actions for selected articles Select all / Deselect allDownload PDFsExport citations...