Hepatic and brain hepcidin mRNA levels also vary across the diurnal cycle and between BXD strains, suggesting a role for hepcidin regulation of iron flux at the BBB epithelial cell. Ferroportin, Ft, DMT1, and TfR are all located in these epithelial cells, and we believe one explanation for ...
Hua+医学大数据 出品 (医学大数据综合分析,HuaPlusMD坚持专业和认真) 参考文献: [1] Using BXD mouse strains in vision research: A systems genetics approach. Eldon E. Geisert, Robert W. Williams. Mol Vis. 2020; 26: 173–187. [2] genenetwork.org/ ...
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In addition, extending the number of available BXD RI strains allows researchers to take advantage of the extensive work that has already been done using these strains and their parental lines. Since the BXD RI strains were also the largest previously available mouse RI population, they have been...
C57BL/6J, DBA/2J, and BXD strains have distinct behavioral performance following non-social chronic stress Adverse events are highly heterogeneous, and behavioral and physiological responses to stress vary with the nature of stressors. To capture the impact of genetics and sex on anxiety-like and...
The strains also differed in the magnitude of the tolerance developed to ethanol-induced hypothermia. Genetic determinants of sensitivity (and tolerance) to different doses of ethanol were primarily independent, although genetic sensitivity and tolerance to the intermediate (2- and 3-g/kg) doses ...
内容提示: 分分类号: R77 学校代码: :1 0 0 6 2 密密 级级: : 学 号号: :2015601025 博 士士学位论文 DOCTORAL DISSERTATION 论文题目: :BXD 小鼠视神经再生的基因背景研究 T I T L E: : Genetic Background of Optic Nerve Regeneration in BXD Mouse Strains 一级学科 : 临床医学 二级学科 : ...
The strains also differed in the magnitude of the tolerance developed to ethanol-induced hypothermia. Genetic determinants of sensitivity (and tolerance) to different doses of ethanol were primarily independent, although genetic sensitivity and tolerance to the intermediate (2- and 3-g/kg) doses ...
GpnmbgeneindifferentstrainsofBXDRImicewas10.92witharangefrom7.91to12.33.Gpnrnb genewasacis-eQTL,andEnd3wasitscandidatedownstreamgene.Moreover,ageneticregulatory networkofGpnmbgenewasconstructedbyfortygeneshighlycorrelatedwithGpnmbgene. Conclusion ThegeneticregulatorynetworkofGpnmbhasbeenconstructed,whichmayprovideaclue...
Most chromosome mapping efforts with the BXD recombinant inbred (RI) strains involve comparisons between a trait of interest and each of a large number of marker loci for evidence of linkage. Such multiple tests or comparisons greatly increase the Type I error rate compared to the single-test si...