Data from these patients who switched from Bosentan 125 mg orally twice per day to macitentan 10 mg orally daily (between October 2013 and February 2015) when macitentan became commercially available were collected. Patients were advised to take their last evening dose of Bosentan and then take ...
The maintenance dose of bosentan for the treatment of PAH is 125 mg b.i.d. Bosentan is rapidly absorbed after oral dosing and reaches peak plasma concentrations of 1317 ng mL1 within 3 h after a single dose.172 Steady-state is reached after 3–5 days and plasma concentrations are then ab...
A model was used to predict cost, ** hospitalisation and mortality rates in patients with idiopathic PAH treated with conventional therapy alone (diuretics, calcium channel antagonists, anticoagulants, supplemental O 2 and/or cardiotonics) or bosentan (Tracleer; initial dosage 62.5mg twice daily, ...
Methods We undertook cost-effectiveness analysis of bosentan (62.5 mg bid during first 4 weeks and 125 mg bid further) and sildenafil (25 mg tid) and estimated incremental cost-effectiveness ratios (ICER) for each drug vs ST. A cohort of 20 patients with PAH, functional class (FC) III ...