In summary, tumour cells cooperate with the tissue microenvironment in bone for survival and persistent growth following metastatic seeding. Dormancy, on the other hand, may largely be due to inefficiency in establishing this cooperation. 3. Macrophage heterogeneity in bone metastasis Macrophages play cr...
Tumour-associated macrophageBone metastasisBreast cancerProstate cancerOsteosarcomaThis overview addresses the recent research developments in the role of tumour-associated macrophages (TAM) in bone metastasis biology and management of breast and prostate cancer as well as in primary and lung metastatic ...
In this Review, we discuss the role of different bone cell types in supporting disseminated tumour cell dormancy and reactivation, and highlight the new opportunities this provides for targeting the bone microenvironment to control dormancy and bone metastasis. This is a preview of subscription ...
1 Introduction Although the skeleton is a common site of metastasis for many solid tumours, metastatic bone disease is particularly relevant in prostate and breast cancers. Thus, bone is the most frequent – and often the only – location of metastasis in patients with advanced prostate cancer. ...
Patients with advanced stage cancers frequently suffer from severe pain as a result of bone metastasis and bone destruction, for which there is no efficacious treatment. Here, using multiple mouse models of bone cancer, we report that agonists of the immune regulator STING (stimulator of interferon...
Genetic or pharmacological modulation of macrophages in vivo results in significant bone phenotypes, and these phenotypes depend on which macrophage subsets are altered. Macrophages are also key mediators of osseous wound healing and fracture repair, with distinct roles at various stages of the repair ...
Among genes included in the bone metastasis signature, the focus here is on those that draw metastatic cells to colonize bone. Evidence that cancer cells acquire bone-like properties to adapt and thrive in the bone microenvironment is also presented. Finally, we discuss the possible contribution ...
The purpose of this dissertation is to define how the macrophage- stimulating protein (MSP) / Ron receptor tyrosine kinase pathway is involved in breast cancer-induced bone destruction and osteoclast activation. These studies employed in vitro osteoclast cultures and in vivo animal tumor models as sy...
MSCs mesenchymal stem cells, M-CSF macrophage colony-stimulating factor, OPG osteoprotegerin, RANKL receptor activator of nuclear factor kappa-B ligand, AGEs advanced glycation end products, ROS reactive oxygen species, SOST sclerostin, GLP-1 glucagon-like peptide-1, GI tract gastrointestinal tract, ...
Prolonged bone metastasis-free survival in men with castrate-resistant prostate cancer treated with denosumab: Results from a phase 3, randomised, double-b... Breaking the `har- mony' of TNF-alpha signaling for cancer treatment. Oncogene 31: 4117- 4127, 2011.Sasi SP, Yan X, Enderling H, ...