即TGF-β可通过上调miR-23a-27a-24的表达,而拮抗其抑制肿瘤的作用,文章发表于International Journal of Cancer 2008, Aug 15; 123 (4): 972-978.);发现多个用于肝癌鉴别诊断及肝癌转移、复发及预后预测的microRNA分子标志物,成功建立了肝癌诊断和肝癌转移、复发及预后预测模型,部分成果发表于International Journal ...
While proliferation is required for tumors to grow, many factors within the tumor microenvironment can influence cellular metabolism, resulting in heterogeneous metabolic activity. Our interest in tumor cells as discussed here involves the metabolic activities that promote their growth and proliferation. ...
(HDR) of double-strand DNA breaks, explaining the sensitivity ofBRCA1-deficient cancers to therapies that block DNA repair, while mutations that restore HDR cause therapy resistance. Research now reveals a mechanistically distinct vulnerability ofBRCA1-deficient cancer cells to gap-inducing DNA nicks....
Cellular metabolism is at the foundation of all biological activities. The catabolic processes that support cellular bioenergetics and survival have been well studied. By contrast, how cells alter their metabolism to support anabolic biomass accumulation
CONCEPT 6.2 Eukaryotic cells have internal membranes that compartmentalize their functions 真核细胞具有内膜,使其功能区室化(Page 97) Comparing Prokaryotic and Eukaryotic Cells 比较原核细胞和真核细胞 (Page 97) A Panoramic View of the Eukaryotic Cell 真核细胞的全景图 (Page 99) ...
Cancer progressionCancer therapyEffective therapies to fight cancer should not be focused specifically on cancer cells, but it should consider the various components of the TME. Non-cancerous cells cooperate with cancer cells by sharing signaling and organic molecules, accounting for cancer progression....
segregation during cell division lead to changes in nuclear features. A study now shows that a mechanosensitive nuclear checkpoint activates the tumour suppressor p53 to halt the proliferation of aneuploid cells. These findings provide mechanistic insights to explore in both ageing and cancer pathologies...
1.1. Overview of the Role of Glial Cells in Alzheimer’s Disease The nervous system is built with two types of cells, i.e., neurons and glial cells. The actual number of glial cells in comparison to neurons has been an unanswered question for a number of years but recent cell counting ...
The dynamic interaction of cancer cells with their microenvironment is essential to stimulate the heterogeneity of cancer cell, clonal evolution, and to increase resistance to therapies. Key components of tumor microenvironment (such as neurons, … ...
Cancer & Metabolism 欢迎研究癌症与代谢关系的各个方面,包括:癌症代谢的分子生物学和遗传学;与癌症有关的全身代谢,包括糖尿病和肥胖症;与癌症有关的代谢组学;基于代谢的代谢相关癌症疗法的成像临床前和临床研究。 该刊已被国际权威数据库SCIE收录,该刊致力于发表经过严格同行评审的高质量原创文章,反映Multiple领域的...