What product is formed when benzene is treated with the given organic halide in the presence of AlCl3? What carbonyl compounds might you start with in a Grignard synthesis of the following compound? 3-phenyl-3-pentanol You do not have to consider stereoc...
H3CO R1 N H Reagent, AlCl3 N grind in mortar 50 min, rt R2 9 10 8 11 12 13 N1 H 76 5 23 N 1 CH3 R3 2-30 CH 14 3 Table 1. Friedel-Crafts acylation of 1 under solvent-free conditions. Entry Reagents Products R1 R2 A (CH3CO)2O B CH3CH2COCl C (CH3-CH2-CH2-CO)2O D...
Interestingly, compounds 17 and 29, which have the methoxy group in the same position were weaker inhibitors—the presence of a hydrophilic electron-donating -OCH3 substituent of the phenyl ring at the para-position decreased the potency of the compounds, especially against the BChE enzyme (see ...