Background and objectives The goal of this literature review is to compare current studies regarding the accuracy of different serum markers in differentiating viral from bacterial pneumonia in the pediatric population with what is employed in the medical settings at present. Currently there is still ...
Consolidation was the most frequent dominant CT finding in both patients with viral and bacterial pathogens, but was observed significantly more often in those with a bacterial pathogen: 32/60 and 22/60 versus 38/48 and 31/48 (p = 0.005; p = 0.004). The lobar pneumonia pattern was more ...
as the prime pathogen, “Captain of the men of death.”1One hundred years later much has changed, but much remains the same. Pneumonia is now the sixth most common cause of death and the most common lethal infection
Bacterial pneumonia is a significant public health burden, contributing to substantial morbidity, mortality, and healthcare costs. Current therapeutic strategies beyond antibiotics and adjuvant therapies are limited, highlighting the need for a deeper understanding of the disease pathogenesis. Here, we emplo...
Measuring host gene expression is a promising diagnostic strategy to discriminate bacterial and viral infections. Multiple signatures of varying size, complexity, and target populations have been described. However, there is little information to indicat
“gut-lung axis”. [15] This interaction offers insights into challenges like refractory asthma and increased vulnerability to both viral and community-spread pneumonia. A standout discovery in this realm is that the microbial metabolite desaminotyrosine has been shown to fortify defenses against ...
phage activates various molecular mechanisms leading to the injection of viral DNA into the host cell. The host metabolism is hijacked to amplify viral DNA and to produce phage proteins. Consequently, phage capsids are assembled and packed with genetic material. After the host cell lysis, the pha...
Bars, +SE (n = 5) and *P < 0.05 ICOVIR15 and ICOVIR17 versus PBS control; P = 0.15 ICOVIR17 versus ICOVIR15 at day 24 (student t-test, two-sided). Bar = 50 μm. Reproduced with permission from Attribution-Non Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) ...
which clearly demonstrates an important role of hormone receptors in the gender bias ofP. aeruginosainduced pneumonia [147]. Therefore, further studies are required to elucidate the participation of hormone receptors in the sexual dimorphism observed in bacterial infections in the respiratory tract that ...
IC50-values of nitrendipine and verapamil, respectively, were 18.2 μM versus 2.8 μM for digoxin transport); analogous data were obtained for other dihydropyridines as compared to verapamil [197,198,199,200]. These data demonstrate that all the calcium-antagonists tested interacted primarily with ...