Quaternary amino acids, in which the alpha-carbon that bears the amino and carboxyl groups also carries two carbon substituents, have an important role as modifiers of peptide conformation and bioactivity and as precursors of medicinally important compounds(1,2). In contrast to enantioselective ...
Miyabe, H.; Ushiro, C.; Ueda, M.; Yamakawa, K.; Naito, T. Asymmetric synthesis of alpha-amino acids based on carbon radical addition to glyoxylic oxime ether. J. Org. Chem. 2000, 65, 176-185.Asymmetric synthesis of alpha-amino acids based on carbon radical addition to glyoxylic oxime...
Stereoselective decarboxylative protonation can produce diverse chiral molecules from widely available carboxylic acids. However, general and practical strategies are lacking. Now, a chiral spirocyclic phosphoric acid-catalysed decarboxylation of aminomalonic acids has enabled the modular synthesis of α-amino...
Kazuyuki Miyashita,Hideto Miyabe,Kuninori Tai,Chiaki Kurozumi,Hiroshi Iwaki,Takeshi Imanishi. Chiral Environment Specifically Induced by Metal Ion: Asymmetric #alpha#-Alkylation of #alpha#-Amino Esters Using Pyridoxal Derivatives Having a Chiral Ionophore Function[J].Tetrahedron 1999,41(41)....
Asymmetric synthesis of a-amino acids by the alkylation of pseudoephedrine glycinamide: L-allylglycine and N-Boc-L-allylglycine (acetamide, 2-amino-N-(2-hy... ChemInform Abstract: Pseudoephedrine-Directed Asymmetric α-Arylation of α-Amino Acid Derivativeshydantoin derivativesamino acids, peptides,...
A highly enantioselective amino acid-catalyzed route to functionalized alpha-amino acids Given that we have shown that a variety of optically active amino acids can be synthesized with proline catalysis, where an L-amino acid begets other ... A Córdova,W Notz,G Zhong,... - 《Journal of th...
Enantiopure Amino AcidsMinor DiastereoisomerTert-butyl Isocyanate伪-Amino nitriles tethered to alkenes through a urea linkage undergo intramolecular C-alkenylation on treatment with base by attack of the lithionitrile derivatives on the N'-alkenyl group. The geometry-retentive alkene shift affords stereo...
Highly enantioselective synthesis of [small alpha]-tertiary chiral amino acid derivatives through rhodium-catalyzed asymmetric arylation of cyclic N-sulfonyl [small alpha]-ketimino estersBy em...
Ligand-Controlled C(sp~3)-H Arylation and Olefination in Synthesis of Unnatural Chiral α-Amino Acids Thesef ligandsouneheeactivityndelectivityfransitionetalatalystsor(sp~3)-Hondunctionalization isentralhallenge inyntheticrganichemistry.erein, weeportare ex... Youqian,Deng,Haiyan,... - 《Scienc...
The straightforward strategy of building a chiral C-O bond directly on a general carbon radical center is challenging and stereocontrol of the reactions of open-chain hydrocarbon radicals remains a largely unsolved problem. Advance in this elementary ste