Modeling Astrocyte-Neuron Interactions in a Tripartite Synapse. BMC Neurosci. 2014, 15 (Suppl 1), P98.M.-L. Linne, R. Havela, A. Saudargien and L. Mc- Daid, Modeling astrocyte-neuron interactions in a tripartite synapse, BMC Neuroscience 15(1) (2014)....
Synonyms Tripartite synapse Definition Classically the roles of astrocytes in neuron–astrocyte interaction in the central nervous system (CNS) have been as passive and supportive elements, which remove the released neurotransmitters by specific transporters (such as GLT-1, a glutamate transporter), ...
astrocyte–neuron interactionFifteen years ago the concept of the "tripartite synapse" was proposed to conceptualize the functional view that astrocytes are ... A Covelo,A Araque - 《Neuroscience》 被引量: 11发表: 2016年 加载更多来源期刊 Current Drug Targets October 2013 研究点推荐 Tripartite S...
The glutamate transporter GLAST in astrocyte regulates synapse function by glutamate clearance. Here, the authors show that Down syndrome cell adhesion molecule (DSCAM) in Purkinje cells controls synaptogenesis through the intercellular association with GLAST in the developing cerebellum. Ken-ichi Dewa , ...
In healthy CNS tissue, astrocytes maintain homeostasis of extracellular fluids, ions, and transmitters [2], provide glucose metabolites as energy substrates to neurons [3], modulate local blood flow [4], help to regulate drainage of interstitial fluid [5], play essential roles in synapse ...
As will be detailed in this review, astrocytes augment neuronal activity at the level of individual neurons in the form of gliotransmission and the tripartite synapse. Under normal conditions, astrocytes are essential to the maintenance of blood-brain barrier integrity and remediation of inflammation ...
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The mechanisms and functional consequences of astrocyte–neuron signaling are more complex than previously thought. Stroke is a disease associated with neurons in which astrocytes also play an important role. Astrocytes respond to the alterations i...
to providing neurons with antioxidant substrates. Astrocytes also modulate neuronal plasticity and are critical for proper synapse formation between neurons, leading to the recent rewrite of scientific textbooks to describe the tripartite synapse7. Furthermore, it has also now been firmly established that...
Intriguingly, it was shown in mature differentiated co-cultures that astrocyte-to-neuron Ca2+ -transmission occurred through a synapse-independent, physical intercellular contact that had at least some characteristics of a gap junction47. Since connexins have been shown to be localized to a subset...