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APP-a-carboxyl terminal fragment (APP-alpha-CTF) associations with ADAM10 and APP-beta-CTF with BACE1 were increased. Levels of ADAM10 and BACE1 mRNA increased in response to the concentrations of 0.25 mM, respectively. In addition, p-ERK and p-Bad (S112, S155) expressions were increased,...
For example, the reduced level of the soluble amyloid precursor protein alpha is evident in our model as well as in AD (12). Additionally, recruitment of the adapter protein FE65 to the cell membrane was suggested to be diminished in AD (13), which is mimicked by the absence of the ...
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The blots were incubated with antibodies against PS1 (AB5308), PS1-NTF, PS1-CTF (PS1-C) [19], APP-BP1 (BP339) [2], nicastrin, or β-catenin followed by ChemiGlow detection (Alpha Innotech). Primary neurons Primary neurons were isolated from E18 rat embryonic brain cortices. The ...
Our studies further demonstrated that geranylgeranyl isoprenoids increase the yield of APP-CTFgamma (a.k.a. AICD) as well as Abeta by stimulating gamma-secretase-mediated cleavage of APP-CTFalpha and APP-CTFbeta in vitro. Furthermore, GGOH increases the levels of the active gamma-secretase ...
AICD 50, AICD 57, AICD 59, AID(50), AID(57), AID(59), Amyloid beta A4 protein, amyloid P, amyloid precursor protein, Amyloid-beta precursor protein, APP, APPI, beta Amyloid, CTFgamma, CVAP, Gamma CTF(50) C31, PN II, PN2, PreA4, Protease nexin II, S APP alpha Soluble APP be...
mo-APP-sgRNA and Cas9 (or non-targeting control-sgRNA/Cas9 as control) and immunoblotted with Y188 and 22C11 antibodies (latter recognizes APP N-terminus). A gamma secretase inhibitor (GSI) was added to allow detection of accumulated APP CTF’s (see methods, GAPDH used as loading controls...
The CTF fragments are subsequently cleaved by γ-secretase and produce Aβ, p3, and APP intracellular c-terminal domain (AICD)5. In mammals, APP has two homologs, amyloid precursor-like proteins 1 and 2 (APLP1 and APLP2)6,7, which are similarly processed by the same secretases, ...
别名Soluble APP-alpha; Soluble APP-beta; A4 amyloid protein; A4; AAA; ABETA; ABPP; AD 1; AD1; Alzheimer disease 1; Alzheimer disease; Alzheimer's disease amyloid protein; Amyloid beta (A4) precursor protein; Amyloid beta A4 protein; Amyloid beta A4 protein precursor isoform b; Amyloid bet...