RANK)信号通路的重要转录因子,其活性可受其他转录因子的调节及信号通路的上游激酶的控制[5-6],其活化后可通过核因子-κB(nuclear factor kappa B,NF-κB)和Jun氨基末端激酶(Jun N-terminal kinase,JNK)、细胞外信号调节激酶(extracellular
AP-1为属于亮氨酸拉链型的转录调控因子,通常结合于DNA,通过被磷酸化而活化。该磷酸化反应通过JNK(c-Jun N-terminal kinase,c-Jun氨基末端激酶)和p38完成,其中,JNK为MAPKK的成员。另一个激酶级联体系为将NF-κB(nuclear factor kappa B,核因子B)活化的级联。NF-κB不结合于DNA,通常与IκB(inhibitor-κB,κB...
肝星状细胞(Hepatic Stellate Cell,HSC)的活化在肝纤维化发生发展过程中占据着重要地位,多种核转录因子如转录激活蛋白-1(Activator protein-1,AP-1)、核因子NF-κB(Nuclear factor-kappa B,NF-κB)等表达增高与HSC的活化有关。由于肝纤维化是一个可逆性的病理过程,所以早期诊断、进行药物干预可防止肝硬化的发生...
英文名:IKKB, phosphorylated (S177) (IKBKB, IKKB, Inhibitor of nuclear factor kappa-B kinase subunit beta, I-kappa-B kinase 2, Nuclear factor NF-kappa-B inhibitor kinase beta) (AP) 中文名: CBNumber:CB04933773 分子式: 分子量:0 MOL File:Mol file IKKB, phosphorylated (S177) (IKBKB, IK...
Cited in 1392 publications. NF-κB p65 antibody for WB, IHC, IF/ICC, IP, ELISA and reacts with human, mouse, rat.
Since kappa enhancers' activation is required for Ig kappa gene expression and their activations are generally considered as B cell lineage-restricted events, and since NF-κB and AP-1 binding sites exist within and downstream the iEκenhancer, and on the basis of our previous findings that both...
Purpose To invesigate the effect of glucocortioid on the nuclear protein level of glucocorticoid receptor (GR), activator protein-1 (AP-1) and nuclear factor-kappa B(NF-kB), and the relationship between this effect and the glucocorticoid sensitivity in idiopathic nephrotic syndrome (INS). Method...
中文名称:NFKB激活蛋白抗体,Anti-NKAP 英文名称:Anti-NKAP 别名: NF-kappa-B-activating protein; Nkap; NKAP_HUMAN; Nuclear NF kappaB activating protein. 宿主来源:Rabbit/Mouse 克隆类型:单抗/多抗 性 状:Lyophilized or Liquid(冻干粉或液体) 浓 度:1mg/ml 亚 型:IgG 产品规格:0.1ml/0.2ml 交叉...
Goat Anti-Rat light chain Antibody Goat anti-Rat light chain Antibody is an antibody against light chain for use in ELISA & WB. - Find MSDS or SDS, a COA, data sheets and more information.
Furthermore, nuclear transcription factor levels of AP-1 and NF-kappa B are elevated in response to this toxicant. 展开 关键词: adrenomedullin nitric oxide hypotension calcitonin gene-related peptide N-G-nitro-L-arginine methyl ester spontaneously hypertensive rat DOI: 10.1016/1359-6446(96)89117-3...