Moreover, TGF-β1 was not down-regulated and administration of neutralizing anti-TGF-β1 antibody, which inhibited tolerance induction (DST), also shortened allograft survival (anti-donor class II antibodies). These results suggest that, in these two MHC class II-restricted models, both T...
Animals are randomly assigned to three groups following with intraperitoneal injection of a specific neutralizing anti-TGF-?antibody 1D11 or control antibody 13C4 respectively at the time of tumor cell injection. Group 1:1D11 (50 mg/kg every 3 days); Group 2:13C4 (50 mg/kg every 3 days...