Anaplastic large cell lymphoma (ALCL), anaplastic lymphoma kinase (ALK)-positive (ALK+ ALCL) is an aggressive CD30-positive T-cell lymphoma that exhibits a chromosomal translocation involving the ALK gene and the expression of ALK protein. No particular risk factor has been clearly identified for...
Anaplastic large cell lymphoma is defined by a proliferation of large pleomorphic blasts and a constant expression of the CD30 molecule on all neoplastic cells, and has been clinically subdivided into a primary form and a secondary form. We are presenting a case of 14-year-old boy with ...
Anaplastic large cell lymphoma (ALCL) is one of the most common subtypes of peripheral T-cell lymphomas (PTCLs). ALCL is an aggressive lymphoma with anaplastic lymphoma kinase-positive (ALK-positive) ALCL generally having a better prognosis and occurring in younger patients than ALK-negative ALCL...
large celllymphomaThis abstract discusses a rare case of anaplastic large cell lymphoma (ALCL) involving the cervical and dorsal spine in a 17-year-old female. ALCL is a distinct subtype of lymphoma characterized by abnormal proliferation of lymphocytes and is divided into ALK-positive and ALK-...
Novel Agents in the Treatment of Relapsed or Refractory Peripheral T-Cell Lymphoma Hematology/Oncology Clinics of North America, Volume 31, Issue 2, 2017, pp. 359-375 Enrica Marchi,…, Owen A. O'Connor Durable brain response with pulse-dose crizotinib and ceritinib in ALK-positive non-small ...
The prognosis for treatment of anaplastic large cell lymphoma The prognosis for anaplastic lymphoma varies according to the type of oncopathology, the spread of the malignant process, response to treatment, age and health status of the patient. The overall 5-year survival rate for ALK-positive pat...
Quantification of minimal disease by digital PCR in ALK-positive anaplastic large cell lymphoma: a step towards risk stratification in international trials? Cancers. 2022;14:1703. Mussolin L, Le Deley MC, Carraro E, Damm-Welk C, Attarbaschi A, Williams D, et al. Prognostic factors in ...
Frequent expression of the NPM-ALK chimeric fusion protein in anaplastic large-cell lymphoma, lympho-histiocytic type. Am J Pathol 1997; 150: 1207–1211. CAS PubMed PubMed Central Google Scholar Mann KP, Hall B, Kamino H, Borowitz MJ, Ratech H . Neutrophil-rich, Ki-1-positive anaplastic...
2.1.1 Anaplastic lymphoma kinase inhibitors Anaplastic lymphoma kinase (ALK), a tyrosine kinase receptor belonging to the insulin family, is related to oncogenesis of human cancers in anaplastic large-cell lymphoma, non-small cell lung cancer (NSCLC) and inflammatory myofibroblastic t...
Anaplastic large cell lymphoma (ALCL) is one of the most common peripheral T-cell lymphomas, and the incidence is higher in blacks than non-Hispanic whites. ALK-positive and ALK-negative ALCL are distinct subtypes that have different characteristics and clinical outcomes. Breast implant-associated ...