Anaplastic large cell lymphoma (ALCL), anaplastic lymphoma kinase (ALK)-positive (ALK+ ALCL) is an aggressive CD30-positive T-cell lymphoma that exhibits a chromosomal translocation involving the ALK gene and the expression of ALK protein. No particular risk factor has been clearly identified for...
Anaplastic large cell lymphomalymphomalarge cellcytodiagnosisimmunohistochemistrychildAnaplastic large cell lymphoma is defined by a proliferation of large pleomorphic blasts and a constant expression of the CD30 molecule on all neoplastic cells, and has been clinically subdivided into a primary form and a...
Anaplastic large cell lymphoma (ALCL) is one of the most common subtypes of peripheral T-cell lymphomas (PTCLs). ALCL is an aggressive lymphoma with anaplastic lymphoma kinase-positive (ALK-positive) ALCL generally having a better prognosis and occurring in younger patients than ALK-negative ALCL...
large celllymphomaThis abstract discusses a rare case of anaplastic large cell lymphoma (ALCL) involving the cervical and dorsal spine in a 17-year-old female. ALCL is a distinct subtype of lymphoma characterized by abnormal proliferation of lymphocytes and is divided into ALK-positive and ALK-...
ALK was originally identified as a part of the fusion oncogene nucleophosmin (NPM)-ALK resulting from a t(2;5) chromosomal translocation in anaplastic large cell lymphomas (ALCL).1 The fusion gene NPM-ALK is detected in approximately 75% of all ALK-positive ALCL and is implicated in the ...
Anaplastic large cell lymphoma (ALCL) is a mature T-cell lymphoma that accounts for 10–15% of childhood lymphomas. Despite the observation that more than 90% of pediatric cases harbor the anaplastic lymphoma kinase (ALK) rearrangement resulting in aberrant ALK kinase expression, there is significa...
The prognosis for treatment of anaplastic large cell lymphoma The prognosis for anaplastic lymphoma varies according to the type of oncopathology, the spread of the malignant process, response to treatment, age and health status of the patient. The overall 5-year survival rate for ALK-positive pat...
Frequent expression of the NPM-ALK chimeric fusion protein in anaplastic large-cell lymphoma, lympho-histiocytic type. Am J Pathol 1997; 150: 1207–1211. CAS PubMed PubMed Central Google Scholar Mann KP, Hall B, Kamino H, Borowitz MJ, Ratech H . Neutrophil-rich, Ki-1-positive anaplastic...
Primary ALK Positive Anaplastic Large Cell Lymphoma of the Pancreas Yossi Cohen, Diana Libster, Gail Amir, Nurith Hiller, Nael Da'as, Dina Ben Yehuda & show all Pages 205-207 | Published online: 01 Jul 2009 Cite this article https://doi.org/10.1080/1042819021000054715 References ...
2.1.1 Anaplastic lymphoma kinase inhibitors Anaplastic lymphoma kinase (ALK), a tyrosine kinase receptor belonging to the insulin family, is related to oncogenesis of human cancers in anaplastic large-cell lymphoma, non-small cell lung cancer (NSCLC) and inflammatory myofibroblastic t...