APH aminoglycoside O-phosphotransferaseaminoglycoside O-phosphotransferasecAPK cyclic AMP-dependent protein kinasecyclic AMP-dependent protein kinase... DL Burk,AM Berghuis - 《Pharmacology & Therapeutics》 被引量: 82发表: 2002年 Structural basis of APH(3')-IIIa-mediated resistance to N1-substituted ami...
Results: A novel aminoglycoside 3′-O-phosphotransferase gene designated aph(3′)-Id was identified in K. intermedia DW18 and shared the highest amino acid identity of 77.49% with the functionally characterized aminoglycoside 3′-Ophosphotransferase APH(3′)-Ia. The recombi...
Escherichia colimultidrug resistanceN-acetyltransferasesO-nucleotidyltransferasesO-phosphotransferasesClin Microbiol Infect 2012; 18: E11–E12doi:10.1111/j.1469-0691.2011.03710.xZ Wang-ShengM Zu-HuangW Xing-BeiClinical Microbiology and Infection
This study was designed to investigate the antimicrobial resistance characteristics and four resistant gene expressions of aminoglycoside-modifying enzymes including N-acetyltransferases and O-phosphotransferases in Acinetobacter baumannii. Methods Bacterial identification and antimicrobial susceptibility test were ...
Desiree HoChi. Fong
The aminoglycoside phosphotransferase encoded by the gene of SEQ ID NO:1 has the amino acid sequence set forth in SEQ ID NO:2. A recombinant expression vector comprises the aminoglycoside phosphotransferase gene of SEQ ID NO:1. A transformant producing the aminoglycoside phosphotransferase is ...
Background High-level gentamicin resistance in enterococci and staphylococci is conferred by AAC(6′)-APH(2″), an enzyme with 6′-N-acetyltransferase and 2″-O-phosphotransferase activities. The presence of this enzyme in pathogenic gram-positive bacteria prevents the successful use of gentamicin ...
Engin H. Serpersu,Can Özen,Adrianne L. Norris,Carlos Steren,Neil Whittemore.Backbone resonance assignments of a promiscuous aminoglycoside antibiotic resistance enzyme; the aminoglycoside phosphotransferase(3′)-IIIa[J]. Biomolecular NMR Assignments .2010(1)...
Engin H. Serpersu,Can Özen,Adrianne L. Norris,Carlos Steren,Neil Whittemore.Backbone resonance assignments of a promiscuous aminoglycoside antibiotic resistance enzyme; the aminoglycoside phosphotransferase(3′)-IIIa[J]. Biomolecular NMR Assignments .2010(1)...
In this study, we identified a new gene (aph(3 '')-Id) coding for a streptomycin phosphotransferase by using phylogenetic comparative analysis of the genome of the oxytetracycline-producing strain Streptomyces rimosus ATCC 10970. Cloning the aph(3 '')-Id gene in E.coli and inducing its ...