In addition, it examines situations when amino acid synthesis is driven through metabolic coupling to other reactions, and synthesis is in excess of the cancer cell's proliferative demand. Finally, it highlights the understudied area of non-proteinogenic amino acids in cancer metabolism and their ...
In this paper, we review the metabolism-related mechanisms of CSCs in order to provide a theoretical basis for their potential application in tumor therapy. 展开 关键词: AMINO acid metabolism CANCER stem cells LIPID metabolism GLUCOSE metabolism CANCER relapse ...
differentiation and function. Amino acid metabolism disorders have been linked with a number of pathological conditions, including metabolic diseases, cardiovascular diseases, immune diseases, and cancer. In the case of tumors, alterations in
Cancer Cell. 2020;37:147–56. CAS PubMed Google Scholar Holeček M. Branched-chain amino acids in health and disease: metabolism, alterations in blood plasma, and as supplements. Nutr Metab. 2018;15:33. Google Scholar Ananieva EA, Wilkinson AC. Branched-chain amino acid metabolism in ...
Using an unbiased proteomic screen, we identified mTORC2 as a critical regulator of amino acid metabolism in cancer via phosphorylation of the cystine-glutamate antiporter xCT. mTORC2 phosphorylates serine 26 at the cytosolic N terminus of xCT, inhibiting its activity. Genetic inhibition of mTORC2,...
Amino Acid Metabolism Amino acid metabolismis generally deregulated and plays an important role during cancer progression. Glutamine plays a key role in many tumor types since it can fuel the oxidativeTCAcycle, contribute to reductivecarboxylation, and alter the NADPH production and redox balance, ther...
Protein Metabolism the sum of the processes of the transformation of proteins and the products of their decomposition—amino acids—in organisms. Protein metabolism is an essential part of metabolism. Since amino-acid metabolism is closely connected with the metabolism of other nitrogen compounds, prote...
Inflammatory burden and amino acid metabolism in cancer cachexia PURPOSE OF REVIEW: Cancer cachexia is associated with marked alterations in skeletal muscle protein metabolism that lead to muscle wasting and, in some cas... WJ Durham,EL Dillon,M Sheffield-Moore - 《Current Opinion in Clinical Nutri...
Branched-chain amino acid (BCAA) catabolism and high levels of enzymes in the BCAA metabolic pathway have recently been shown to be associated with cancer growth and survival. However, the precise roles of BCAA metabolism in cancer growth and survival remain largely unclear. Here, we found that...
18F-FDG PET/CT has been used as an indicator of chemotherapy effects, but cancer cells can remain even when no FDG uptake is detected, indicating the importance of exploring other metabolomic pathways. Therefore, we explored the amino acid metabolism, in