IMPORTANCE OF THE FIELD: Alzheimer's disease is the leading cause of dementia in the elderly, and there is no disease-modifying therapy yet available. Immunotherapy directed against the beta-amyloid peptide may be capable of slowing the rate of disease progression. Bapineuzumab, an anti-beta-...
Alzheimer's Disease is characterized by a general decline in cognitive functioning. Although phonology are relatively unaffected, patients with Alzheimer's Disease have been reported to have deficits of semantic memory. Thirteen patients with dementia, five of whom had a confirmed diagnosis of dementia...
INTRODUCTION: Subcortical hyperintensities (SHs) are radiological entities commonly observed on magnetic resonance imaging (MRI) of patients with Alzheimer's disease (AD) and normal elderly controls. Although the presence of SH is believed to indicate some form of subcortical vasculopathy, pathological he...
Amyloid plaques associated with Alzheimer's disease (AD) induce inflammatory responses associated with activated microglia and reactive astrocytes, which exacerbate neurodegeneration through release of inflammatory cytokines, reactive oxygen species, and other factors. Inflammation contributes to neurodegeneration ...
One of the most difficult, distressing and frightening situations for home caregivers or staff in care facilities is aggressive or combative behavior from someone who has Alzheimer's disease. Aggression such as shouting, raising a hand to someone, pushing, biting and hitting, is not uncommon amongs...
Glycogen synthase kinase 3 ~2 (GSK-3 Beta) is a potential target for developing an effective therapeutic effect in Alzheimer's disease (AD). Currently, no such drug or molecules has been found till date which can cure AD completely. Few drugs such asacetylcholinesterase inhibitors and memantine...
Advanced glycation end products (AGE) and the receptor for AGE (RAGE) have been implicated in the chronic complications of diabetes mellitus (DM), and have been reported to play an important role in the pathogenesis of Alzheimer's disease (AD). In this study, we established a polyclonal anti...
ClinicalTrials数据库提供临床试验APOE in the Predisposition to, Protection From, and Prevention of Alzheimer's Disease的登记号NCT04994847,试验分期以及申办者Banner Health的信息,更过关于临床试验的其他信息查询就在戊戌数据美国临床试验数据库.
Except here, the baker and the butcher are geriatric nurses and specialists trained to deal with the symptoms of Alzheimer’s disease and dementia, which can manifest themselves as disorientation and occasionally aggressive behaviour. There are a handful of such places scattered round the world, thou...
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