Retrograde melanosome transport toward the microtubule minus-ends at the cell center is accomplished by dynein and dynein-associated proteins, and this process can be used to evaluate melanosome motility within pigmented cells.29, 30, 31 In RPE cells, melanosome motility is achieved by RPE ...
HTN may also facilitate the transfer of Aβ from blood to brain through the receptor for advanced glycation products (RAGE).61 Cerebral hypoxia-ischemia, which can occur with HTN, can also facilitate β-secretase–mediated cleavage of Aβ from its precursor protein and increases the brain Aβ ...
While accumulated Aβ causes glucose metabolic disorder by disturbing the insulin signaling pathway, altered glucose metabolism can conversely promote Aβ accumulation. Our histological examination showed that glucose utilization increased with emerging Aβ deposition but attenuated with growing Aβ plaques, ...