Adipocyte hypertrophy plays an important role in regulating cells’ lipid storage and secretion of adipose-specific hormones/factors that contribute to systemic energy balance, inflammation, and energy homeostasis. On the other hand, adipocyte hyperplasia, termed adipogenesis, is known to contribute to ...
Obesity is characterized by the enlargement ofwhite adipose tissue(WAT) depots with excess engorgement of lipids in adipocytes. In addition, excess intake of energy leads to increase in adipocyte size (hypertrophy) and eventually the number of adipocytes (hyperplasia). High levels of adipose tissue ...
Summary1. Adipocyte hypertrophy and hyperplasia are important processes in the development of obesity. To understand obesity and its associated diseases, it is important to elucidate the molecular mechanisms governing adipogenesis. MicroRNA-375 has been shown to inhibit differentiation of neurites, and ...
19.Rongchang pig's adipocyte hypertrophy function in subcutaneous adipocyte cells was stronger than in DLY pig's. 荣昌猪皮下脂肪细胞的肥大作用强于DLY猪。 20.The expression decrease of IGF2 may be related to adipocyte hyperplasia. IGF 2基因表达水平的降低可能与脂肪细胞的增殖有关。 相关词 ...
White adipose tissue (WAT) expansion in obesity occurs through enlargement of preexisting adipocytes (hypertrophy) and through formation of new adipocytes (adipogenesis). Adipogenesis results in WAT hyperplasia, smaller adipocytes and a metabolically mor
AT expands through hypertrophy and hyperplasia (an increase in adipocyte number through de novo differentiation). Hypertrophic adipocytes exhibit reduced expression of fat identity genes that leads to an impaired capacity to store excess lipid, and release inflammatory adipokines to aggravate AT microenviron...
Depot- and obesity-related differences in adipogenesisdoi:10.2217/clp.12.49adipocyteadipogenesiswhyperplasiaobesityPPARγAdipocyte hypertrophy and hyperplasia are known to facilitate lipid storage in adipose tissues by increasing adipocyte cell size and number, respectively. Adipogenesis is the process resulting...
Expansion of adipose tissue during obesity through the recruitment of newly generated adipocytes (hyperplasia) is metabolically healthy, whereas that through the enlargement of pre-existing adipocytes (hypertrophy) leads to metabolic complications. Accumulating evidence from genetic fate mapping studies suggests...
Expansion through hyperplasia associates with a benign metabolic phenotype, while expansion through hypertrophy promotes obesity-associated metabolic complications (2). Hyperplasic adipose tissue expansion is mediated by several adipogenic events including recruitment, proliferation, and/or differentiation of new...
As obesity progresses, adipose tissues grow by hypertrophy (increasing the size of their adipocytes) and by hyperplasia (increasing the number of adipocytes) [75], [76], [77], [78], [79]. A yearly adipocyte turnover rate for lean and obese humans of 10% has been reported [79], but ...