Topical clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide (BPO) 3.1% gel (IDP-126) is the first fixed-dose triple-combination in development for acne. Objective: To confirm efficacy, safety, and toler
acnes when compared to 1% clindamycin gel.29 Multiple studies have shown that, when combined with topical clindamycin, benzoyl peroxide treatment resulted in decreased P. acnes counts and improvement in number of lesions.30,31 In addition, with the concomitant use of benzoyl peroxide and clindamycin...
Clindamycin phosphate (CLIN) 1.2%/adapalene (ADAP) 0.15%/benzoyl peroxide (BPO) 3.1% gel (CAB) is the only triple-combination topical approved for acne. These post hoc analyses assessed efficacy and safety of CAB gel compared with component dyads and branded ADAP 0.3%/BPO 2.5% gel in ...
Exposure of adapalene to other topical anti-acne drugs such as erythromycin, clindamycin phosphate or benzoyl peroxide does not produce any mutual degradation. Absorption of adapalene through human skin is low (see section 5.2 Pharmacokinetic properties) and therefore interaction with systemic medication ...
agent or contraction irritating substances can cause additional irritation. Therefore, use other skin medication early in the morning such as erythromycin (concentrations ≤4%), clindamycin phosphate (1%) aqueous solution or benzoyl peroxide gel (concentration ≤10%); Use Duff Man gel at night so ...
Ex vivo skin deposition of the prepared ADA-OPTMS gel and ADA-gel was evaluated using the tape stripping method utilizing mice dorsal abdominal skin excised as a diffusion membrane. The skin was defrosted, equilibrated with pH 7.4 phosphate buffer solution, and then fitted to a Franz diffusion...
Ex vivo skin deposition of the prepared ADA-OPTMS gel and ADA-gel was evaluated using the tape stripping method utilizing mice dorsal abdominal skin excised as a diffusion membrane. The skin was defrosted, equilibrated with pH 7.4 phosphate buffer solution, and then fitted to a Franz diffusion...
Duac® Gel is a viscous, opaque, white to slightly yellow, aqueous gel containing both clindamycin phosphate (equivalent to clindamycin 1% and benzoyl peroxide 5%). Clinical studies of the use of Duac® Gel have demonstrated a reduction in Acne vulgaris lesions with tolerability within acceptable...
CLINDAMYCINPEROXIDESQUALITY of lifeHYPERPHOSPHATEMIABackground/Objectives: Topical clindamycin phosphate 1.2%/benzoyl peroxide 3.1%/adapalene 0.15% gel (IDP-126) is the first fixed-dose triple-combination formulation in development for acne. This post hoc analysis investigated efficacy and safety of IDP-...
For the 4-week initial treatment, 1% clindamycin phosphate gel was applied twice daily and 0.1% adapalene gel, once. In the 4-week maintenance phase, patients were randomly assigned to the OD group (adapalene applied once daily) or the TW group (adapalene applied once daily on 2 days per ...