Acute myeloid leukemiaWeight lossAnemiaAML is characterized by a clonal proliferation of myeloid precursors with a reduced capacity to differentiate into more mature cellular elements. We present a case in which the association of weakness, weight loss, and anemia conduct to the diagnosis of AML in...
Acute Myeloid Leukemia (AML) is a bone marrow malignancy characterized by the infiltration of the bone marrow, blood and other tissues by clonal cells of the myeloid lineage with limited or no potential for differentiation [1]. From:Leukemia Research,2022 ...
Acute myeloid leukemia (AML) is a type of blood cancer that starts in your bone marrow, which is the soft inner part of your bones where all your blood cells are made. AML usually begins in cells that turn into white blood cells but can also start in other blood-forming cells. When b...
急性髓系白血病(Acute myeloid leukemia, AML)是最常见的白血病类型之一,且难以治愈。AML的特征在于快速增长的异常细胞,积聚在骨髓和血液中,进而干扰正常血细胞。其症状包括感到疲倦,呼吸急促,容易瘀伤和出血以及感染风险增加。AML的进展较为迅速,如果不及时治疗,通常会有生命危险。 临床研究,指任何在人体(病人或健康志...
Acute Myeloid Leukemia Diane C. Farhi GENERAL FEATURES Nomenclature Acute leukemia arising from myeloid cells has been variously referred to as myeloblastic, myelocytic, and myeloid, with little, if any, clarification as to the meaning implied by these different terms. In this chapter, the overall ...
Interaction of c-Myb with p300 is required for the induction of acute myeloid leukemia (AML) by human AML oncogenes The MYB oncogene is widely expressed in acute leukemias and is important for the continued proliferation of leukemia cells, suggesting that MYB may be a th... DR Pattabiraman...
Acute myeloid leukemia( AML ) is a clonal and heterogeneous disease characterized by a myriad of genetic defects. 急性髓性白血病 ( acutemyeloid leukemia, AML ) 是一类起源于造血干细胞的、以大量遗传缺陷为特征的异质性恶性血液病. 互联网 Methods: Induction regiment ofacute myeloid leukemia( AML ) co...
Primary or “de novo” AML refers to myeloid leukemia arising in the absence of an antecedent myeloid neoplasm, without a mutational pattern strongly linked with sAML, and without prior exposure to leukemogenic therapies. From: Clinics in Laboratory Medicine, 2022 ...
Little is known about how leukemia cells alter the bone marrow (BM) niche to facilitate their own growth and evade chemotherapy. Here, we provide evidence that acute myeloid leukemia (AML) blasts remodel the BM niche into a leukemia growth-permissive and normal hematopoiesis-suppressive microenvironm...
急性髓系白血病(Acute myeloid leukemia, AML)是一种以髓系祖细胞克隆扩增和分化阻滞为特征的骨髓恶性疾病【1】。其具有高遗传异质性和复杂的克隆进化特征【2】。AML是成人急性白血病中最常见的一种形式,生存期最短 (5年生存期仅 24%)。包括强化化疗和异基因干细胞移植在内的治疗性治疗通常适用于少数年轻和健康的...