The acid-catalyzed hydrolysis of methyl isonitrile has been examined. The initial hydrolysis product is N-methylformamide which is further hydrolyzed to methyl amine and formic acid at a much slower rate. The hydrolysis to N-methylformamide is pseudo-first order in methyl isonitrile and shows a...
The Strecker amino acids synthesis consists of the treatment of aldehydes with ammonia and hydrogen cyanide (or their equivalents), and subsequent hydrolysis of the intermediate α-amino nitriles, providing the α-amino acids. From:Tetrahedron,2006 ...
The mechanism for the acid-catalyzed hydrolysis of 2-methoxy-3,3-dimethyloxetane (43), which is a cyclic acetal, has received detailed study 〈74JA819〉. Kinetic studies in buffered media and solvent deuterium isotope effects demonstrated that this reaction showed general acid catalysis, which had...
Fig. 1: Alkene aminoalkylcarbonylation and synthesis ofγ-amino acid derivatives. ARepresentative drugs demonstrating the ubiquity ofγ-amino acid derivatives.BChemical synthesis routes toγ-amino acids.CThe challenges and conception of this work.DThis work: cobalt-catalyzed aminoalkylcarbonylation of alk...
Visual representation of the active centres is shown in Fig. S4. Catalytic results The bifunctional NH2/Zr-M reactors were tested in the tandem deacetalization-Knoevenagel condensation reaction. In this process, benzaldehyde (BA) obtained in hydrolysis of acetal (BDMA), reacts directly with ethyl...
Efficient dehydra- tion of aldoximes to nitriles catalyzed by a Lewis acid ionic liq- uid. Chemistry Letters, 2011, 40(4): 396-397.Nakajima, M.; Qiao. K., Bao, Q.; Kobayashi, N.; Bao, Q.; Tomida, D.; Yokoyama, C.Efficient dehydration of aldoximes to nitriles catalyzed by a ...
Kinetics of hydrolysis of o-tolunitrile in moderately concentrated perchloric acid solutionskinetics, optimization of reactionsNo abstract is available for this article.doi:10.1002/chin.197436073BUNNETT J. F.OLSEN F. P.WILEY‐VCH Verlag GmbHThe Journal of Organic Chemistry...
(Fig.2). The next two steps involve oxidative decarboxylation of isocitrate to α-ketoglutarate and α-ketoglutarate to succinyl-CoA. Furthermore, succinyl-CoA is converted into SA with production of GTP, and the reaction is catalyzed by succinyl-CoA synthetase. In the next step, SA is ...
Bonnet-Delpon and coworkers191–193 described a Wittig reaction of N-trifluoroacetylmorpholine 78.1 followed by hydrolysis that afforded on work up trifluoromethyl ketone 78.4. A sequential carbonyl ene cyclization of trifluoromethyl ketone was catalyzed by aluminum Lewis acids. Thus, the Me2AlCl or ...
Thus, the acid-catalyzed hydrolysis of 2,4,6-triaminopyrimidine 170 occurred in the 2-position to give 4,6-diamino-2(1H)-pyrimidinone 171 <2001JOC192>. Examples of selective diazotization of diamines are also known <2005JOC1612>. Sign in to download full-size image Alkoxides are ...