This gene located on human chromosome 12 is a protein-coding gene that consists of seven exons. And it can regulate the fibril formation by interacting with collagen fibrils and other extracellular matrix proteins14. EPYC has been found to function crucial roles in a variety of human diseases, ...
Despite the increased number of transcripts, one of the limitations of AtRTD3 is the incomplete coverage of genes and transcripts by Iso-seq as seen in the saturation curve (Additional File 2: Figure S6A). Importantly, ca. 80% of protein-coding, unproductive mRNA, and ncRNA transcripts in ...
Schumacher B, Hofmann K, Boulton S, et al. TheC. eleganshomolog of the p53 tumor suppressor is required for DNA damage-induced apoptosis[J]. Curr Biol, 2001, 11(21): 1722−1727. DOI:10.1016/s0960-9822(01)00534-6. [31] Ahmed S, Hodgkin J. MRT-2 checkpoint protein is required ...
Advances in structural biology, genetics, bioinformatics, etc. resulted in the availability of an enormous pool of information enabling the analysis of the
The pathological process of Alzheimer’s disease (AD) typically takes decades from onset to clinical symptoms. Early brain changes in AD include MRI-measurable features such as altered functional connectivity (FC) and white matter degeneration. The abili
A specialized dietician instructed all patients to adhere to a personal tailored energy and carbohydrate restricted and, if necessary, protein and fiber enriched diet. Based on the patients’ preference, daily routine, and body mass index, dietary advice plan A or B was chosen. If necessary, the...
Soil microbiomes are highly diverse, and to improve their representation in biogeochemical models, microbial genome data can be leveraged to infer key functional traits. By integrating genome-inferred traits into a theory-based hierarchical framework, em
Despite the importance of the catalytic activity of a protein, it is still difficult to pinpoint its functional residues and create mutants that can increase the catalytic activity from the protein sequences. The main reason for this is that the positive residues that contribute to catalytic effect...
Serendipita indica induced metabolic reprogramming in colonized plants complements phosphorus-management in improving their tolerance to arsenic stress on
Urine protein-to-creatinine ratio (PCR) or ACR is commonly used to quantify the level of proteinuria. However, the cost of a PCR or ACR test renders it unsuitable for use in screening for proteinuria in a public health context. On the other hand, the urine dipstick test is a simple and...