Both postmating shrinking and transcriptional changes require piRNA pathway function, implying that the germline pro-aging signal must be related to piRNAs. Since the pro-aging signal is amplified in mated germ
The evolution of a protein may provide clues to its function. GbE appears to be restricted to birds because no ortholog could be identified in the sequences from any other vertebrate class. Surprisingly, no GbE was detected in the genome of Anolis. However, currently we cannot decide whether ...
Abdominal aortic aneurysm Myeloid-related protein (MRP) 8/14 MRP8 MRP14 MMP-2 MMP-9 1. Introduction Abdominal aortic aneurysm (AAA) is a common arterial degenerative disease, especially for the elderly men with 2% of the prevalence. AAA has a high mortality rate as for aortic rupture, which...
Soil microbiomes are highly diverse, and to improve their representation in biogeochemical models, microbial genome data can be leveraged to infer key functional traits. By integrating genome-inferred traits into a theory-based hierarchical framework, em
Higher mitochondrial levels of manganese in aMDMs pointed to a functional role of the superoxide dismutase 2 (SOD2) in the context of macrophage activation. The amount of SOD2 protein increased in mitochondria upon activation, whereas the amount of catalase decreased (Fig. 3a,b). Mitochondrial ...
Serendipita indica induced metabolic reprogramming in colonized plants complements phosphorus-management in improving their tolerance to arsenic stress on
Exosomes are extracellular vesicles generated by all cells and they carry nucleic acids, proteins, lipids, and metabolites. They mediate the exchange of substances between cells,thereby affecting biological properties and activities of recipient cells. I
Soft-shelled turtle iridovirus (STIV) is the causative agent of severe systemic diseases in cultured soft-shelled turtles (Trionyx sinensis). To our knowledge, the only molecular information available on STIV mainly concerns the highly conserved STIV major capsid protein. The complete sequence of...
44. A protein's primary structure, which is a linear sequence of amino acids, contains the structural and functional data that the protein needs to function properly. Deep learning models like CNN and recurrent neural networks (RNN) have been successfully applied to protein sequences for several...
This polymorphism may modify the effect of folate, vitamin B6, or vitamin B12 on the development of CRC [11]; however, the function of the polymorphism remains unknown. CRC is a serious health concern in Thailand, where it is one of the fifth most common cancers in the last 2 decades. ...