1 Interactions of 5-HT1A receptor agonist or antagonist with diltiazem on pentobarbital-induced LORR. (a) Effects of 8-OH-DPAT, diltiazem and their co-administration on pentobarbital-induced LORR in mice. Mice received diltiazem (2 mg/kg, p.o.) for 90 min and 8-OH-DPAT (0.5 mg/kg, i...
Disclosed is a compound represented by the formula (1) or a pharmaceutically acceptable salt thereof, which can act as a 5-HT1A receptor agonist (serotonin 1A agonist) and is useful as a therapeutic or prophylactic agent for a mood disorder such as anxiety disorder and depression, a psychotic...
These compounds differ in their balance of 5-HT1A/D2 receptor affinity and agonist or antagonist properties; such differences are likely to translate into distinct therapeutic profiles. The balance of 5-HT1A/D2 receptor properties should therefore be considered when selecting compounds ...
*5-HT1A受体下调:抑郁症患者的中枢缝核和前额叶皮层中5-HT1A受体密度减少,这可能与5-羟色胺能神经递质系统功能障碍有关。 *5-HT1A受体功能障碍:抑郁症患者的5-HT1A受体功能减弱,导致5-羟色胺释放的负反馈调节受损。 *5-HT1A受体多态性:5-HT1A受体基因(HTR1A)的某些多态性与抑郁症易感性有关,提示5-HT1A受体...
FLIBANSERIN : ANTIDEPRESSANT 5-HT1A RECEPTOR AGONIST 5-HT2 RECEPTOR ANTAGONIST Purpose: We assessed the neuroprotective effects of Flibanserin (BIMT-17, Addyi), a dual 5-HT1A agonist and 5-HT 2A antagonist, in a light-induced retinopathy mouse model. Methods: Albino BALB/c mice and 5-HT1A KO...
KR Bentley,DNM Barnes - 《Cns Drugs》 被引量: 71发表: 1995年 Testosterone and its metabolites modulate 5HT1A and 5HT1B agonist effects on intermale aggression. Receptor, Serotonin, 5-HT1BAggressionSerotonin Receptor AgonistsMaleOur understanding of the neurochemical and neuroendocrine systems' regul...
The recovery of this parameter, which is attributable to 5-HT(1A) autoreceptor desensitization, also restores 5-HT release. At this point, the summed effects of a normalized level of synaptic 5-HT and the exogenous 5-HT(1A) agonist can be exerted on postsynaptic 5-HT(1A) receptors. The...
The sustained administration of the 5-HT1A agonist gepirone (15 mg/kg/day, s.c.) in the rat produced an initial decrease of the firing activity of dorsal r... P Blier,CD Montigny - 《Synapse》 被引量: 1093发表: 1987年 Parametric Imaging of Ligand-Receptor Interactions Using a Reference...
Effect of Sarizotan, a 5-HT1a and D2-Like Receptor Agonist, on Respiration in Three Mouse Models of Rett Syndrome Rationale: Disturbances in respiration are common and debilitating features of Rett syndrome (RTT). A previous study showed that the 5-HT1a receptor agonis... AP Abdala,DT Lioy...
Here, we further investigate the role of 5-HT1A autoreceptors in the acute and chronic stimulant effects of cocaine using 5-HT1A receptor ligands in autoreceptor preferring doses. In experiment 1, four groups of rats (N = 10) received either saline or the 5-HT1A agonist, 8-OHDPAT (...