A marked difference between this protozoal MTA phosphorylase and the mammalian counterpart is its ability to synthesize and cleave 2'-deoxyadenosine. . 1985 International Pediatrics Research Foundation, Inc.doi:10.1203/00006450-198507000-00123George
5′-脱氧-5′-甲基硫腺苷(MTA)已被证明是蛋白质羧甲基转移酶的强抑制剂和多胺生物合成的天然副产物。据报道,这种核苷通过引起细胞凋亡强烈抑制某些细胞的生长。用该化合物处理细胞可抑制cAMP磷酸二酯酶,随后增加cAMP水平,导致细胞生长停止。更具体的研究表明,5′-脱氧-5′-甲基硫腺苷处理的细胞在细胞周期的M期显示...
Finally, a structural comparison of AtMTAN2 performed with previously determined structures of AtMTAN1 and an E. coli homolog provides clues for the substrate specificity of MTA nucleosidases in A. thaliana.ParkE.Y.ChoiW.S.S.I.KimK.