2,2-Bis(4-azabenzimidazole) derivatives 9a,b and 10a were isolated as by-products of the protonhalogen exchange. Treatment of the N1- or N3-methyl-4-azabenzimidazoles 1a,b with methyl lithium and N-chlorosuccinimide as a chlorine source proceeded to give 2-chloro-4-azabenzimidazoles 11a,b ...
ChemInform Abstract: Synthesis and Coordination Chemistry of 4-Azabenzimidazole Derivativesfused pyridine derivativesamination, N-alkylation, N-arylationA facile method for the synthesis of the title compounds (III) and (IV) is presented.doi:10.1002/chin.201140158...
摘要: The present invention is directed to compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined 5 herein. The compounds of formula I are useful as inhibitors of PDE4 for the treatment of CNS and other disorders....
原料品名 5-AZABENZIMIDAZOLE 原料中文名称 1H-咪唑[4,5-C]吡啶 中文别名 1H-咪唑[4,5-C]吡啶;5-氮杂苯并咪唑;5-氮杂苯并咪唑,98%;1H-咪唑并[4,5-C]吡啶;5-氮杂苯并咪唑 5G 化学名称 3H-imidazo[4,5-c]pyridine 分子式 C6H5N3 分子量 119.12 CAS号 272-97-9 结构式图片 暂无...
英文别名NSC 521774 | CL3548 | AKOS009158089 | YTTRIUMSULFATEOCTAHYDRATE | SCHEMBL1927520 | 1H-imidazo[4,5-c]pyridin | imidazo(4,5-c]pyridine | 3H-imidazolo[4,5-c]pyridine | AS-20058 | EN300-88369 | 5-Azabenzimidazole, 97% | 3,5-DIAZAINDOLE | FT-0620034 | imidazo[ ...
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PURPOSE:To provide a new azabenzimidazole derivative having antagonistic action on angiotensin II and useful for the prevention and treatment of hypertension, chronic cardiac insufficiency, etc. CONSTITUTION:The objective compound is expressed by formula I [R<1> is H or alkyl; R<2> is H or ...
pad4 aza-benzimidazole inhibitorsThe present invention relates to compounds useful as pad4 inhibitors, their compositions and methods of treating pad4-related disorders.ADRIAN KOTEYCRISTINA LECCIGNANASAMBANDAM KUMARAVELHEATHER TYEIAN WIGGINTONLAURA GLEAVE...
FT-IR and FT-Raman spectroscopic and DFT theoretical studies on 4-azabenzimidazoleYurdakulS.BadogluSPECTROCHIMICA ACTA PART A
Aza-benzimidazole inhibitors of PAD4The present invention provides compounds useful as inhibitors of PAD4, compositions thereof, and methods of treating PAD4-related disorders.Rajesh DevrajGnanasambandam KumaravelLaura GleaveAdrian KoteyThomas Krulle...