(E)-4-Hydroxytamoxifen基础信息 中文名：阿非莫昔芬;雌激素受体调节剂;英文名：(E)-4-Hydroxytamoxifen;Estrogen receptor modulator;Afimoxifene;4-OHT;(E/Z)-4-hydroxy Tamoxifen CAS号：174592-47-3 结构式：OC1=CC=C(C=C1)/C(C2=CC=C(C=C2)OCCN(C)C)=C(CC)\C3=CC=CC=C3 分子式：C26H29...
Synonym (English)(Z)-4-OHT, (Z)-4-(1-[4-(Dimethylaminoethoxy)phenyl]-2-phenyl-1-butenyl)phenol, trans-4-Hydroxytamoxifen Beilstein Registry No- EINECS Number- MDL NumberMFCD00278780 UNSPSC Code- 产品描述(Description): Biochem/physiol Actions4-羟基他莫昔芬(4-HT)是他莫昔芬的活性代谢产物,...
英文别名: 4-Hydroxytamoxifen;(Z)-4-(1-[4-(Dimethylaminoethoxy)phenyl]-2-phenyl-1-butenyl)phenol;(Z)-4-Hydroxy Tamoxifen;trans-4-Hydroxytamoxifen;(Z)-4-OHT;(Z)-4-Hydroxytamoxifen;Afimoxifene;Hydroxytamoxifen;4-Monohydroxytamoxifen;Tamogel;Ici 79280;(E/Z)-4-Hydroxytamoxifen;4-OH-TAM;(Z...
1) OHT 4-羟基他莫昔芬 1. Objective: To investigate the effects of 4OH-Tamoxifen(OHT) on proliferation and apoptosis of primary cultured prostate stromal cells. 目的:研究4-羟基他莫昔芬(OHT)对原代培养的前列腺基质细胞增殖与凋亡的影响。
英文名:(E)-4-Hydroxytamoxifen;Estrogen receptor modulator;Afimoxifene;4-OHT;(E/Z)-4-hydroxy Tamoxifen CAS号:174592-47-3 结构式:OC1=CC=C(C=C1)/C(C2=CC=C(C=C2)OCCN(C)C)=C(CC)\C3=CC=CC=C3 分子式:C26H29NO2 分子量 :387.51 ...
英文别名:4-Hydroxytamoxifen;(Z)-4-(1-[4-(Dimethylaminoethoxy)phenyl]-2-phenyl-1-butenyl)phenol;(Z)-4-Hydroxy Tamoxifen;trans-4-Hydroxytamoxifen;(Z)-4-OHT;(Z)-4-Hydroxytamoxifen;Afimoxifene;Hydroxytamoxifen;4-Monohydroxytamoxifen;Tamogel;Ici 79280;(E/Z)-4-Hydroxytamoxifen;4-OH-TAM;(Z)...
Synonym (Chinese) (Z)-4-(1-[4-(二甲氨基乙氧基)苯基]-2-苯基-1-丁烯基)苯酚, 反式-4-羟三苯氧胺, (Z)-4-羟三苯氧胺 Synonym (English) (Z)-4-OHT, (Z)-4-(1-[4-(Dimethylaminoethoxy)phenyl]-2-phenyl-1-butenyl)phenol, trans-4-Hydroxytamoxifen Beilstein Registry No - EINECS ...
英文名:(E)-4-Hydroxytamoxifen;Estrogen receptor modulator;Afimoxifene;4-OHT;(E/Z)-4-hydroxy Tamoxifen CAS号:174592-47-3 结构式:OC1=CC=C(C=C1)/C(C2=CC=C(C=C2)OCCN(C)C)=C(CC)\C3=CC=CC=C3 分子式:C26H29NO2 分子量 :387.51 ...
结论:OHT可能通过结合GPR30后激活Src蛋白,进而磷酸化激活ezrin,介导细胞骨架重构并促进MCF-7细胞迁移。[关键词】4.羟基他莫昔芬;G蛋白偶联受体30;Ezrin蛋白[中图分类号]Q279[文献标志码]Adoi:10.3969/j.issn.1000—47l8.2014.05.0064.Hydroxytamoxifen.stimulatedactivati0n0fezrinismediatedviaG.pro.tein—coupled...
4 OHT激活ezrin蛋白磷酸化 分别用DMSO(0.1%)及0.1、1、5、10和15 μmol/L OHT处理MCF-7细胞30 min,检测其是否能快速磷酸化激活MCF-7中的膜-细胞骨架蛋白ezrin。 Westren blotting结果显示1、5和10 μmol/L OHT能显著增加p-ezrin蛋白的表达,其最大效应浓度约为5 μmol/L。用OHT(1 μmol/L)分别处理MCF...