本申请提供了特异性结合在人T细胞表面上表达的4‑1BB的结合分子,以及这样的结合分子在特异性和强效刺激和激活原代人T细胞中的用途。本申请进一步提供了编码这样的结合分子的多核苷酸。 (19)国家知识产权局 (12)发明专利申请 (10)申请公布号CN117255804A (43)申请公布日2023.12.19 (21)申请号202280031805.5(74)...
Epidemiological studies have shown a strong correlation between tumor and AF. However, the molecular link between tumor and AF remains unknown. ECRG4, a tumor suppressor gene that is expressed in the A-V node and in sporadic ventricular myocytes, inhibit
Combined CD28 and 4-1BB costimulation potentiates affinity-tuned chimeric antigen receptor-engineered T cells. Clin Cancer Res. 2019;25:4014–25. CAS PubMed PubMed Central Google Scholar Klebanoff CA, Gattinoni L, Torabi-Parizi P, Kerstann K, Cardones AR, Finkelstein SE, et al. Central ...
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Finally, E3 catalyses the covalent binding of ubiquitin to the target protein [1]. E3 ligases are divided into three main families: zinc-binding RING finger adaptor (a recently discovered gene) [2], HECT (homologous with the carboxyl end of E6AP) catalytic [3] and U-box (a modified ...
Beqvez(通用名:fidanacogene elaparvovec)是一款用于基于AAVrh74的腺相关病毒(AAV)基因治疗药物。 2024年1 月3日,辉瑞宣布,加拿大卫生部批准Beqvez上市,用于治疗18岁或以上中重度至重度乙型血友病成人患者,这些患者体内需确认不带有靶向腺相关病毒(AAV)血清型 Rh74 亚型的中和抗体。
265 -- 3:25 App Looperj GRAND BEATBOX BATTLE 2018 LOOPSTATION WILDCARD 151 1 8:15 App SPIDERHORSE vs COSTIK STORM Grand Beatbox TAG TEAM Battle 2017季军争夺赛 3.4万 147 8:07 App HISS vs ALEXINHO 2017GBBB个人组半决赛 1.2万 15 1:25 App GENE VS WAWAD 宇宙最强弹舌battle 900 4 ...
37, No. 11 e80 A 20000 18000 16000 14000 12000 10000 8000 6000 4000 2000 0 0 B 3000 2500 GMAPX EM GMAPX+sim4cc EM+sim4cc 0.2 0.4 0.6 0.8 Gene Coverage 1 GMAPX EM GMAPX+sim4cc EM+sim4cc 2000 1500 1000 500 0 0 0.2 0.4 0.6 0.8 Gene Coverage 1 Figure 3. Number...
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cervical cancer cells by miR-125b/BAK1 pathway Y-D Wang1,3, N Cai1,3, X-L Wu1, H-Z Cao1, L-L Xie1 and P-S Zheng*,1,2 Octamer-binding transcription factor 4 (OCT4) is a key regulatory gene that maintains the pluripotency and self-renewal properties of embryonic stem cells. ...