由上海科州药物研发有限公司申报的1类创新药妥拉美替尼胶囊,通过优先审评审批程序附条件批准,获批商品名为科露平,适用于含抗PD-1/PD-L1治疗失败的NRAS突变的晚期黑色素瘤患者。 该产品为我国自主研发的首款MEK抑制剂、全球首个且唯一获批针对...
These effects were independent of ERK1/2, which were classic downstream of MEK1/2. These investigations proposed a mechanism that MEK1/2 regulated inflammation via non-transcriptional regulation of NLRP3 inflammasome and might help better understanding the effects and side-effects of MEK inhibitors ...
Model 3 ima iste značajke koje naša ostala vozila čine tako sigurnim: bočne pragove koji apsorbiraju energiju, pojačani paket baterije koji je nisko montiran u vozilu, kako bi se smanjio rizik od prevrtanja, te metalnu konstrukciju karoserije koja može izdržati više...
Memleket ve milletin kurtuluşu ve mutluluğu için çalışmaktan başka bir amacım yoktur. Bu, bir insan için yeterli bir sevinç ve zevk sağlar. Benimle beraber olan arkadaşlarım, bütün vatandaşlarım da aynı amacı izlemektedirler. Kişisel ve ai...
Mitogen-activated protein kinase (MAPK) cascades play an important role in innate immunity against various pathogens in plants and animals. However, we know very little about the importance of MAPK cascades in plant defense against viral pathogens. Here,
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Stimulation of neoplastic mouse lung cell proliferation by alveolar macrophage-derived, insulin-like growth factor-1 can be blocked by inhibiting MEK and PI3K activation Mol. Cancer, 10 (2011), p. 76 View in ScopusGoogle Scholar [122] A.M. Houghton Mechanistic links between COPD and lung cance...
Username for 'https://gitee.com': userName Password for 'https://userName@gitee.com': # 私人令牌 master 分支(1) 标签(4) 管理 管理 master v1.1.1 v1.1.0 v1.0.1 v1.0.0 vue3-element-admin / package-lock.json package-lock.json 220.20 KB ...
EuO is not stable under ambient conditions19, much less the oxygen-rich high-temperature environment neces- smeaannrateythilaofeolgnpra,yntohotnefreofdovueritpamebooalseitftiabiooprnnipnsrougoficanchcrghaytssiontEgavueloltOilhnv2eee1rsLtsotatarAsiotlloanObrgi3inl2fi0egz.reHarnoaomciwnoaetngevfn...
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