EE2-Sul was also assessed as an efflux transporter substrate using membrane vesicles expressing bile salt export pump, breast cancer resistance protein (BCRP), and individual forms of multidrug resistance-associated protein (MRP1, MRP2, and MRP3). Transport studies were also conducted with a cell ...
It led to lasting impairment of spleen growth and differentiation that can be attributed to an interaction of EE2 with IGF-I and, less pronouncedly, IGF-II. Especially, the impairment of spleen and melanomacrophage centres might interfere with the antigen presentation capacity of the immune system...
Feng Y, Zhang Z, Gao P, Su H, Yu Y, Ren N (2010) Adsorption behavior of EE2 (17alpha-ethinylestradiol) onto the inactivated sewage sludge: kinetics, thermodynamics and influence factors. J Hazard Mater 175(1–3):970–976CrossRef Fent K, Escher C, Caminada D (2006) Estrogenic activity...
This study provides a comparative analysis of the effects of 17-alpha ethinyl estradiol (EE2) and diethyl phthalate (DEP) on neuronal cell proliferation and neurotoxicity. Using differentiated SH-SY5Y human neuronal cells, we evaluated cell viability, microRNA (miRNA) regulation, and RNA expression ...
The synthetic estrogen 17伪-ethinylestradiol (EE2) and the environmental carcinogen benzo[ a ]pyrene (BaP) are exogenous EDs whereas the estrogenic hormone 17尾-estradiol is a natural endogenous ED. Although the biological effects of these individual EDs have partially been studied previously, their...
In parallel, the ER-regulated expression of cytochrome P450 aromatase B (AroB) protein, which is encoded by the cyp19a1b gene, was precisely mapped at the brain and pituitary levels in developing control and EE2-exposed zebrafish. We show that EE2 disrupts the ontogeny of GnRH syst...
Reduction in EE2 bioavailability was correlated with computed surface area of nC(60), and reduced bioavailability of EE2 upon aging was consistent with absorption of EE2 within nC(60) aggregates. Size and zeta potential of nC(60) particles were affected by EE2 (1 mu g/L) and also by ...
In this study we investigated effects of single and combined exposures of silver (Ag) nanoparticles (AgNPs) and the synthetic hormone 17 alpha -ethinylestradiol (EE2) on tissue uptake of both contaminants in juvenile turbot (Scophthalmus maximus). Silver uptake and tissue distribution (gills, liver...
Pregnant mice were treated per os with EE2 at 0.01, 0.1 or 1 渭g/kg/day, between embryonic days 10.5 (E10.5) and E13.5, a period during which GnRH-1 neurons are generated and start their intra-nasal migration. Embryos at E13.5 were examined and processed for GnRH-1 ...
The aim of the present study was to assess the responses of the gonopodium morphology and the gonadal and liver histology of adult male Cnesterodon decemmaculatus to sublethal long-term exposure concentrations of 17 alpha-ethinylestradiol (EE2). Two experiments were conducted exposing the fish to...