Bars represent means ± SD of 4 mice per group and are representative of 2 independent experiments with similar results for each indicated time point. shown that Ang II plays a pivotal role in regulating the T cell response in an autocrine or paracrine manner via AceTll1sR, ,suwch...
(A) Time course (0–15 min) of acute pain behaviors (duration of licking or biting) after the administration of capsaicin or its vehicle (DMSO 1%, dose 0). (B) Latency to paw withdrawal in response to the application of a punctate mechanical stimulus at 0.5 g force 15 min ...
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Results showed that CBL0100 alone moderately blocks acute infection and inhibits HIV-1 reactivation by LRAs, and intensifies the activity of ART. Therefore, CBL0100 in combination with ART could promote faster viral clearance, and alone or in combination with other LPAs could block...
survival of myofibroblasts through inhibition of apoptosis and proliferation of activated hepatic stellate cells (HSC) [10] but also modulates sinusoidal endothelial cells and immune cells during the recovery from acute liver injury [11]. Previous publications have shown that a microtissue consisting of...
Our data show, for the first time, that δ-Ctenitoxin-Pn1a is able to induce antinociception in inflammatory, neuropathic and acute pain models. Keywords: spider toxin; δ-Ctenitoxin-Pn1a; PnTx4(6-1); Phoneutria nigriventer; spider venom; antinociception 1. Introduction The word pain ...
Interestingly, PC is a ligand of the pentraxin C-reactive protein (CRP), an acute phase protein present in human blood that is a widely used clinical marker for inflammation [9,10]. We found that endogenous CRP-PC complexes are potent nAChR agonists that also inhibit the ATP-dependent ...
pharmaceuticals Article Unexpected Binding Mode of a Potent Indeno[1,2-b]indole-Type Inhibitor of Protein Kinase CK2 Revealed by Complex Structures with the Catalytic Subunit CK2α and Its Paralog CK2α Jennifer Hochscherf 1, Dirk Lindenblatt 1, Benedict Witulski 1, Robin Birus 2, Dagmar Aiche...
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