cells were partially lysed (Fig.1e), with concomitant expansion of anti-γδ CAR-T cells (Fig.1f). A marked downregulation of γδ TCR expression was noted on surviving γδ T cells (Fig.1g). Interestingly, by contrast, at lower E:T ratios (1:2 and 1:4), paradoxical γδ T cell...
gamma-delta (γδ) T cells have emerged as potential players in neuroinflammation28,29. γδ T cells are a subset of lymphocytes bearing a T cell receptor composed of gamma (γ) and delta (δ) chains as opposed to alpha (α) and beta (β) chains found...
Mutations are the most common genetic alteration seen in PCGDTCL, while structural abnormalities such as gene fusions are not common. We report a case of PCGDTCL with atypical immunophenotypic features, including expression of CD5 with lack of cytotoxic marker expression, and a structural ...
To test this possibility, we carried out co-culture experiments with murine colonic epithelial cells (CT26 line) grown in the bottom well and immunocytes (from mice mesenteric lymph nodes [MLNs]) grown in the inserts (upper well). The idea was to understand the effect of epithelial SENP7 ...
In metastatic colorectal cancer, γδT cells still show the ability to limit tumor progression [5]. By analyzing 25 kinds of cancers (other than brain cancers), it was found that a tumor-related γδT-cell gene signa- ture was the factor most correlated with the OS rate of patients [...
It also leaves their TcRs intact and available for identifying the cells. The use of gene inactivation to destroy certain γδ T cell subsets has other potential problems, in that it generates an animal in which development may have been altered by congenital lack of this cell type, a real...