DBCO azF-CCR5 氮杂二苯并环辛烯(DBCO)标记azF-CCR5变体 DBCO-FLAG (NH2-DYKDDDDKC-COOH) 多肽修饰二苯基环辛炔 DBCO-PEG4-FLAG, Dibenzylcyclooctyne-PEG4-FLAGtag (DYKDDDDK) 多肽-四聚乙二醇-二苯基环辛炔 有cRGD环肽的二苯并环辛烯(DBCO containing cRGD) PLL-OEG-DBCO 聚赖氨酸-低聚(乙二醇)(OEG)和...
SOLUTION: This compound is represented by formula I [Y is -COOH, -PO3 H2 , -P(O)(OR<6> )(OH); R<6> is a 1-4 alkyl; X is NH, O, S; R is H, -C(O)NHC6 (R<7> )5 ; R<7> is H, OH, a halogen] and formula II (R<1> -R<5> is H, OH a halogen, -COOH,...
X-ray analysis shows the COOH-terminal leucine to be in equilibrium between two positions: one with the salt bridge between the terminal carboxyl and Lys C5(40)alpha intact and the leucyl side chain leaning against main chain atoms of helices F and FG and the other with the terminal salt ...
本发明中使用的术语“氨基酸”是指含有氨基(-nh2)和羧基(-cooh)官能团以及每 个氨基酸特有的侧链的有机化合物。氨基酸名称在本发明中也以标准的单字母或三字母代码表示,总结如下: [0076][0077][0078] 术语“多肽”、“肽”和“蛋白质”在本发明中互换使用以指代氨基酸残基的聚合物。这些术语还适用于其中一个或...
R5 is Hydrogen or COOH; ar is phenyl or Cyclohexyl phenyl optionally FUSED heterocycle, a 5 - or 6 - member containing one or more heteroatoms each independently selected from o, s and N, while the portion bic u00edclica optionally merged co N phenylHeterocycle or a 5 - or 6 - member...