Cell Meter Beta-Arrestin蛋白易位GPCR信号检测试剂盒是一套基于β-Arrestin蛋白易位机制，结合荧光标记检测的细胞信号转导分析系统。其核心组成包括：荧光标记的β-Arrestin融合蛋白表达质粒 GPCR激动剂/拮抗剂处理体系 荧光成像试剂和缓冲液 当GPCR受体被激动剂激活后，β-Arrestin蛋白会从胞质转移至细胞膜或内涵体中，本...
β-arrestin(一种细胞质蛋白)与激活的受体的结合使GPCR信号失活,并启动了受体向细胞内的易位,在此细胞中配体被去除,受体被循环回到细胞膜。通过将荧光标记(例如GFP)附着到β-arrestin,可以检测受体arrestin复合物的位置。由于脱敏仅发生在激活的受体上,因此检测β-arrestin的易位和随后的受体再循环提供了检测GPCR靶标...
产品名称 Cell Meter Beta-Arrestin蛋白质易位GPCR信号检测试剂盒 产品类型 标准品 产品规格 100 Tests 有效成分含量 95% 是否进口 是 用途范围 科研试剂 级别 超纯、高纯 含量 95% 特色服务 免费技术咨询 顺丰包邮 溶剂 Water 存储条件 在零下15度以下保存, 避免光照 适用仪器 荧光显微镜 是否危...
β -Arrestins are associated with numerous aspects of GPCR signaling and regulation, and accordingly influence diverse physiological and pathophysiological processes. The objective of this study was to determine whether b -arrestins a re involved in GPCR-mediated beta-amyloid peptide generation in vitro...
Beta-arrestin is a multifunctional adapter protein well known for its role in G-protein-coupled receptor (GPCR) desensitization. Exciting new evidence indicates that β-arrestin is also a signaling molecule capable of initiating its own G-protein-independent signaling at GPCRs. One of the best-...
Further, when the new kits are leveraged as part of PerkinElmer’s comprehensive range of GPCR solutions, users can fully characterize the GPCRs being studied -- from ligand binding with the Tag-Lite® platform, and 2nd messenger with the cAMP and IP-One™ kits, to downstre...
品名:PathHunter eXpress MC4R U2OS Beta-Arrestin GPCR Assay 规格:1,000 dp (10 x 96-well) 货号:93-0211E3CP0L 一、我们关于PathHunter eXpress MC4R U2OS Beta-Arrestin GPCR Assay蛋白、试剂盒、补体的声明 我们致力于成为科研试剂搜索、采购一体化解决方案提供商!
Beta Arrestin 2 is a member of arrestin/beta-arrestin protein family, which are expressed at high levels in the central nervous system (CNS) and play a critical role in the regulation of G-protein coupled receptors (GPCRs) including MOR. Beta Arrestin 2 is an adaptor protein that is import...
G protein-independent, arrestin-dependent signaling is a paradigm that broadens the signaling scope of G protein-coupled receptors (GPCRs) beyond G proteins for numerous biological processes. However, arrestin signaling in the collective absence of funct
通过调节受体脱敏和重敏过程来调节激动剂介导的G蛋白偶联受体(GPCR)信号传导的功能。在同源脱敏过程中,β-抑制蛋白与gprk磷酸化受体结合,并在空间上阻止其与同源G蛋白的耦合;这种结合似乎需要额外的受体决定簇,仅在活性受体构象中暴露。β-抑制蛋白通过作为内循环适配器(钩环、网格蛋白相关的分类蛋白)和将gprcs招募...