Curr Opin Cell Biol. 13:139-45.Miller, W. E. and Lefkowitz, R. J. (2001). Expanding roles for beta-arrestins as scaffolds and adapters in GPCR signaling and trafficking. Curr. Opin. Cell Biol. 13, 139-145.Miller
nucleus to promote gene transcription and cell proliferation. In contrast, β-arrestin-mediated 50 Erk1/2 activation is slower in onset, requiring 5-10 min to reach maximal level, persists more 51 than one hour and mainly occurs in the cytosol (5, 8, 9). However, Erk1/2 signaling el...
Molecular cell researchZheng M, Zhang X, Sun NN, Min C, Zhang X, Kim KM (2016) RalA employs GRK2 and b-arrestins for the filamin A-mediated regulation of trafficking and signaling of dopamine D2 and D3 receptor. Biochim Biophys Acta 1863: 2072 - 2083...
In this study we discovered a novel protein interaction between the glucocorticoid receptor and β-arrestin-1, a scaffold protein with a well-established role in G-protein-coupled receptor signaling. Using co-immunoprecipitation and in situ proximity ligation assays in A549 cells, we observed that ...
beta-arrestins are a family of adaptor proteins that regulate the signaling and trafficking of various G protein-coupled receptors (GPCRs). They consist of beta-arrestin1 and beta-arrestin2 and are considered to be scaffolding proteins. beta-arrestins regulate cell proliferation, promote cell ...
The overall goal of the study is to understand the role of β-arrestins (intracellular scaffolding cell signaling proteins) in inflammation and pathogenesis of sepsis and colitis using mouse models. Using polymicrobial sepsis model, we have demonstrated that both β-arrestin (β-arr) 1 and 2 ...
β -Arrestins are associated with numerous aspects of GPCR signaling and regulation, and accordingly influence diverse physiological and pathophysiological processes. The objective of this study was to determine whether b -arrestins a re involved in GPCR-mediated beta-amyloid peptide generation in vitro...