α-MSH (alpha-melanocyte-stimulating hormone) 作为内源性神经肽,是一种内源性 melanocortin receptor 4 (MC4R) 激动剂,具有抗炎、解热作用。α-MSH 是前阿皮黑素皮质激素 (POMC) 的翻译后衍生物。 Alpha-促黑激素 CAS:581-05-5 分子式:C77H109N21O19S 分子量:1664.907 Sequence :Ac-Ser-Tyr-Ser-Met-...
Define Alpha-msh. Alpha-msh synonyms, Alpha-msh pronunciation, Alpha-msh translation, English dictionary definition of Alpha-msh. n. Abbr. MSH A hormone secreted by the pituitary gland that regulates skin color in humans and other vertebrates by stimulat
The expression of the alpha-MSH membrane receptor MC1R but not MC2R, MC3R, or MC4R increased distinctively during the osteogenic differentiation from 3, 7 to 14 d. Treatment with alpha-MSH promoted the differentiation and mineralization of MC3T3-E1 cells by increasing the activity of ALP, ...
The native peptides α-melanocyte-stimulating hormone (α-MSH) and γ-melanocyte-stimulating hormone (γ-MSH) each are known as the native agonist for the type 1 (MC1r), the type 3 (MC3r), the type 4 (MC4r) and the type 5 (MC5r) melanocortin receptors (MCr's). The MCr's belong...
Recent advances in genomics and proteomics have suggested that highly selective ligands for the melanocortin 4 receptor (hMC4R), both agonists and antagonists, may have applications to a variety of disease states including obesity, anorexia, sexual dysfunction, pain and other problems. The primary lig...
MC4R Uses alpha-Melanocyte Stimulating Hormone amide is an endogenous melanocortin receptor agonist (Ki values are 0.12, 31, 660 and 5700 nM for MC1, MC3, MC4 and MC5 receptors respectively). Anti-inflammatory peptide; antagonizes proinflammatory mediators, including TNF-α, IL-6 and NO and ind...
Bremelanotide is a melanocortin receptor (MCR) agonist that nonselectively activates several receptor subtypes with the following order of potency: MC1R, MC4R, MC3R, MC5R, MC2R. At therapeutic dose levels, binding to MC1R and MC4R is most relevant. Neuro
α-MSH (alpha-melanocyte-stimulating hormone) 作为内源性神经肽,是一种内源性 melanocortin receptor 4 (MC4R) 激动剂,具有抗炎、解热作用。α-MSH 是前阿皮黑素皮质激素 (POMC) 的翻译后衍生物。 Alpha-促黑激素 CAS:581-05-5 分子式:C77H109N21O19S ...
The primary ligands for the hMC4R receptor are peptides derived from proopiomelanocortin (POMC) especially alpha-MSH and gamma-MSH. We have been interested in developing such peptide and peptidomimetic ligands for many years and have evaluated several different templates. Many years ago we suggested...
Design and synthesis of novel alpha-MSH peptide analogs highly selective for the hMC4RThe highly functionalized [5.9.5] tricyclic diterpenoids (卤)-jatrophatrione and (卤)-citlalitrione have been synthesized. The route begins with the tandem anionic oxy-Cope rearrangement/methylation/transannular ene ...