A straightforward approach towards #-amino-"-keto esters via acylation of chelated amino acid ester enolates. Synthesis 2012, 600-604.Schultz, K.; Stief, L.; Kazmaier, U. A straightforward approach towards α-amino-β-keto esters via acylation of chelated amino acid ester enolates. Synthesis...
A general and practical synthesis of both syn- and anti-alpha-amino beta-hydroxy esters with high levels of selectivity by the use of Ru-SYNPHOS catalysts is reported.The key transformations include asymmetric hydrogenations of alpha-N-sub-stituted beta-keto esters protec...
Analysis of the kinetics for the asymmetric hydrogenation of beta-keto esters over Pt nanoparticles (NPs) in the liquid-phase reveal a unique reaction pathway that is active on alpha-amino acid-functionalized Pt NPs but absent on "ligand-free" Pt NPs. Differences in both the apparent activation...
In the presence of a secondary amine, treatment of alpha-keto esters with fluoroalkanesulfonyl azides at room temperature afforded N-sulfonyl protected beta-amino-alpha-keto esters in good to excellent yields. This reaction provided a novel, direct and convenient access to N-sulfonyl protected beta...
Also provided are methods for preparing such esters and amides and for incorporating them into peptides.WILLIAM A. NUGENTAdam R. LookerRaymond E. ForslundTheodore A. MartinotCristian L. HarrisonSheree Ibrahim
Paris, M.; Pothion, C.; Michalak, C.; Martinez, J.; Fehrentz, J.-A.; " Synthesis of Cyanoketophosphoranes, Precursors of β-Amino-α-keto-esters from UNCAs., " Tetrahedron Lett. 1998, 39, 6889-6890.Paris, M.; Pothion, C.; Michalak, C.; Martinez, J.; Fehrentz, J.-A.;...
Consecutive catalytic electrophilic fluorination/amination of β-keto esters: toward α-fluoro-α-amino acids?[J] . Dominique Pascal Huber,Kyrill Stanek,Antonio Togni.Tetrahedron: Asymmetry . 2006 (4)D. P. Huber,K. Stanek,A. Togni.Consecutive Catalytic Electrophilic Fluorination/Amination ofβ-Keto...
HYDROXYESTERSELUCIDATIONA total synthesis of sulfobacin A, a von Willebrand factor receptor antagonist, is described. Our synthetic approach relies uniquely on catalytic asymmetric reactions for the creation of the three stereogenic centers without using chiral building blocks. The key steps of this ...
Chemoselective synthesis of 6-amino(alkoxy)-1,4,5,6-tetrahydropyridines from cyclic beta-alkoxyvinyl alpha-ketoesterTetrahydropyridinesPyranalpha-KetoestersANRORCThe synthetic versatility of ethyl 2-(2-ethoxy-3,4-dihydro-2H-pyran-5-yl)-2-oxoacetate for the synthesis of ethyl 2-oxo-2-(1-alkyl...