Synucleinopathies are characterized by the accumulation of insoluble alpha-synuclein (alpha Syn). To test whether alpha Syn aggregates modulate synaptic activity, we used a recently developed model in primary neurons for inducing alpha Syn pathology. Wedemonstrated that preformed fibrils (PFFs) ...
Furthermore, comparison between young and aged mice injected with m-alpha-Syn PFFs revealed that PI intervals rather than aging correlate with oligodendroglial alpha-Syn aggregation. These results provide novel insights into the pathological mechanisms of oligodendroglial alpha-Syn aggregation in MSA....