Administration of alpha-naphthylisothiocyanate (ANIT) to rats results in periportal cholangiolitic hepatopathy. Inflammation is a hallmark of the liver injury, and expression of toxicity is dependent on blood neutrophils. The role of other cellular mediators of inflammation in ANIT-induced hepatic ...
Administration of alpha-naphthylisothiocyanate (ANIT) to rats results in periportal cholangiolitic hepatopathy. Inflammation is a hallmark of the liver injury, and expression of toxicity is dependent on blood neutrophils. The role of other cellular mediators of inflammation in ANIT-induced hepatic ins...
伪-naphthylisothiocyanate (ANIT) kills rat liver cells in culture. Testing of a variety of related compounds revealed that toxicity depended upon the isothiocyanate group. The toxicity of ANIT was similar on several lines of cultured cells and in the presence of inhibitors and inducers of ...
Recently, 18β-Glycyrrhetinic acid (18b-GA), a major metabolic component of glycyrrhizin, which is the main ingredient of licorice, was reported to protect against alpha-naphthylisothiocyanate (ANIT)-induced cholestasis. However, its protective mechanism remains unclear. We hypothesized that 18b-GA ...
Intrahepatic cholestasis, alpha-naphthyl isothiocyanate (ANIT), lipidomics, aryl hydrocarbon receptor (Ahr) Ultra-performance liquid chromatography coupled with electrospray ionization quadrupole mass spectrometry (UPLC-ESI-QTOF MS)-based lipidomics was employed to elucidate new mechanism of alpha-naphthyl ...
alpha-Naphthylisothiocyanate (ANIT) causes cholestasis and injury to bile duct epithelium and hepatic parenchymal cells in rats. The mechanism of toxicity is unknown. Neutrophils (PMNs) infiltrate periportal regions of the liver after ANIT intoxication. Because PMNs play a causal role in other extrah...
All rats were randomly divided into six groups—(1) control (n=6), (2) control+200mg/kg andrographolide (n=6), (3) alpha-naphthylisothiocyanate (ANIT)-control (n=6), (4) ANIT+50mg/kg andrographolide (n=6), (5) ANIT+100mg/kg andrographolide (n=6), and (6) ANIT+200mg/kg...
In the current study, we examined the effects of alpha-naphthylisothiocyanate (ANIT)-induced liver injury on intestinal adaptation in a rat model of SBS. Methods Male rats were divided into four groups: Sham rats underwent bowel transection ( n =8), Sham liver-injury rats underwent bowel ...
We gavaged 50mg/kg ANIT to mimic cholestatic liver injury in rats. Seven days after treatment, all the rats were killed. Serum biochemistry and hepatic histopathological assays were performed to evaluate liver injury. We observed that 200mg/kg andrographolide significantly decreased the level of ...
To investigate if andrographolide impairs cholestatic liver injury. All rats were randomly divided into six groups-(1) control (n = 6), (2) control+ 200 mg/kg andrographolide (n = 6), (3) alpha-naphthylisothiocyanate (ANIT)-control (n = 6), (4) ANIT + 50 mg/kg andrographolide (n...