Whereas kifunensine (16, Scheme 6) binds to α-mannosidase I as a strong inhibitor in the 1C4 chair conformation, it is a rather poor inhibitor of Golgi α-mannosidase II (Ki 5.2 mM), where it was found to complex as a 1,4B boat (PDB 1PS3).286 1-Deoxymannojirimycin (11), con...
This chapter is focused on the N -glycan processing enzymes, ER α-mannosidase I (MAN1B1), and three Golgi α1,2-mannosidases (Golgi α-mannosidase IA (MAN1A1), Golgi α-mannosidase IB (MAN1A2), and Golgi α-mannosidase IC (MAN1C1)). Brief mention of the related EDEM proteins (...
DRP Tulsiani,SC Hubbard,PW Robbins,O Touster 摘要: Current evidence indicates that the trimming of mannosyl residues from intermediates in the biosynthesis of the N-linked oligosaccharides of glycoproteins occurs in the Golgi complex. We now present evidence that mannosidase II (Tulsiani, D. R. ...
Single nucleotide polymorphism-mediated translational suppression of endoplasmic reticulum mannosidase I modifies the onset of end-stage liver disease in a... Single nucleotide polymorphism-mediated translational suppression of endoplasmic reticulum mannosidase I modifies the onset of end-stage liver disease in...