伪-Dicarbonyl compounds can be used to covalently modify and thereby inactivate prenylating enzymes such as protein farnesyltransferase and protein geranylgeranyltransferase. The compounds can be designed to enhance affinity and/or specificity for a particular protein substrate.Seth Rose...
alpha-Dicarbonyl compounds were trapped with o-phenylenediamine to give stable quinoxalines of d-arabino-hexos-2-ulose (glucosone), N(6)-(3,6-dideoxyhexos-2-ulos-6-yl)-l-lysine, 1-deoxy-d-erythro-2,3-hexodiulose (1-deoxyglucosone), 3-deoxy-d-erythro-hexos-2-ulose (3-deoxyglucos...
Oxidative Stress and Diabetes Mellitus : A Possible Role of α-Dicarbonyl Compounds in Free Radical Formation ARAKI Atsushi Japanese journal of geriatrics ... A Araki - 《Japanese Journal of Geriatrics》 被引量: 14发表: 1997年 Role of Oxidative Stress in the Genesis of Atherosclerosis and Diabete...
The preparation of a phosphorylated alpha-dicarbonyl compound designed to specifically react with arginine residues of enzymes accepting phosphorylated compounds as effectors is reported, and shown to inhibit rabbit muscle aldolase in a time-dependent and irreversible manner. This irreversible inhibition ...
ChemInform Abstract: EXCITED ELECTRONIC STATES OF THE ALPHA-DICARBONYLSstructure (organic substancesketones (benzene compoundsindan derivativesNois available for this article.doi:10.1002/chin.197438069ARNETT, J. F.NEWKOME, G.MATTICE, W. L.MCGLYNN, S. P....
α-Dicarbonyl compounds, particularly methylglyoxal (MGO), glyoxal (GO), and 3-deoxyglucosone (3-DG), are highly reactive precursors for the formation of advanced glycation end products (AGEs). They are formed in vivo and during food processing. This study aimed to investigate the role of int...
Several dicarbonyl compounds, e.g. the α-keto aldehydes (I), the dialdehydes (III), and the diones (V), are treated with 2-propanol and catalytic amounts of zirconocene or hafnocene dihydride, performing a Meerwein-Ponndorf-Verley-type reduction to give selectively oxo alcohols such as ...
Meerwein-Ponndorf-Verley-type reduction of dicarbonyl compounds to hydroxy carbonyl compounds and .alpha.,.beta.-unsaturated carbonyl compounds to allylic ... Tatsuya Nakano ET AL: " Meerwein-Ponndorf-Verley-type reduction of dicarbonyl compounds to hydroxy carbonyl compounds and .alpha.,.beta.-...
alpha-Dicarbonyl compoundsPhenolic compoundsFree amino acidsSucrose degradationCookies are baked at elevated temperatures to obtain a desirable browning and flavor development, which are provided by Maillard reaction and caramelization. The drawback here is the formation of alpha-dicarbonyl compounds, and ...
alpha-Dicarbonyl compoundsMethylglyoxalGlyoxalBeveragesSoy milkMethylglyoxal (MGO) and glyoxal (GO), alpha-dicarbonyl compounds found in the Maillard reaction, progressively and irreversibly modify proteins. Beverages are an exogenous source of alpha-dicarbonyl compounds and may potentially increase MGO and ...