alpha-Conotoxin TxIB specifically blocked alpha 6/alpha 3 beta 2 beta 3 acetylcholine receptors (nAChRs), and it could be a potential probe for studying addiction and other diseases related to alpha 6/alpha 3 beta 2 beta 3 nAChRs. However, as a peptide, TxIB may suffer from low stability,...
alpha-CTx TxIB blocked alpha 6/alpha 3 beta 2 beta 3 nAChR with an IC50 of 28 nM. In contrast, the peptide showed little or no block of other tested subtypes at concentrations up to 10 mu M. The three-dimensional solution structure of alpha-CTx TxIB was determined using NMR spectroscopy...
The invention relates to alpha-conotoxins from Hainan province for specific blockage of a acetylcholine receptor and application thereof, in particular to application of alpha-conotoxins LtIA for specific blockage of (alpha)2(beta)3. nAChRs, application of alpha-conotoxins TxIB for specific blockage...
αO-conotoxin GeXIVA[1,2] was isolated in our laboratory from Conus generalis, a snail native to the South China Sea, and is a novel, nonaddictive, intramuscularly administered analgesic targeting the α9α10 nicotinic acetylcholine receptor (nAChR) with