New alpha,alpha'-disubstituted amino acids with silylated side chains have been synthesized in racemic form. Starting from a Schiff base of glycine tert-butyl ester, a large variety of alpha,alpha'-dialkylated amino acids has been obtained, depending on the alkylating reagents. The application of...
Asymmetric Synthesis of alpha,alpha-Disubstituted alpha-Amino Acids Using...Discusses the asymmetric synthesis of alpha,alpha-disubstituted alpha-amino acids using (S,S)-cyclohexane-1,2-diol as a chiral auxiliary. Synthetic strategy; Asymmetric alkylation of acyclic beta-keto esters; Synthesis of ...
Several alpha,alpha-disubstituted amino acids were synthesized in high overall chemical yield and optical purity. 展开 关键词: CHIRAL STATIONARY-PHASE STEREOSELECTIVE-SYNTHESIS ENANTIOSELECTIVE SYNTHESIS ASYMMETRIC-SYNTHESIS STEREOSPECIFIC SYNTHESIS ALKYL-ARYL DERIVATIVES REAGENT MECHANISM PEPTDEES DOI: 10.1021...
doi:US3328436 AERLEMANN GUSTAVFAHRNI PETERSCHNIDER OTTOUSUS3328436 * 1963年12月6日 1967年6月27日 Hoffmann La Roche alpha, alpha-disubstituted-beta-amino propionic acids
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alpha-disubstituted-alpha-amino acids and imidazolines derived from oxazol -5(4H) -ones MICHIGAN STATE UNIVERSITY Jetze J. Tepe FiskJason ScottThe research presented in this dissertation focuses primarily on the development of new synthetic organic methodology utilizing oxazol-5(4H)-ones for the ...
The obtained adducts can be then efficiently transformed into protected N-hydroxy α,α-disubstituted α-amino acid derivatives as well as into the corresponding α,α-disubstituted α-amino acids.doi:10.1055/s-2002-25358Portoles, R.Murga, J....
The diethylzinc-promoted reaction of dehydroamino acid derivatives with acid anhydride or pi-allyl palladium complex proceeded smoothly to afford alpha,alpha-disubstituted amino acids via a radical and anionic carbon-carbon bond-forming processes. The tandem reductive reaction of ...
N-DISUBSTITUTED DERIVATIVES OF .alpha.-AMINO ACIDSBERTRAND, FRANCOIS-ROBERT
amino acids, peptidesThe (12-20)-nonapeptide Z-Leu-Aib-Pro-Val-Aib-Aib-Glu(OBzl)-Gln-Pheol (10) of the ionophor alamethicin was synthesized by a new strategy, using 3-amino-2,2-dimethyl-2H-azirines 2 as synthons for the alpha-aminoisobutyric acid (Aib) moieties.doi:10.1002/chin....