For 12-week-old females, a trend was present, but the difference was not statistically significant. Similar results were found for the colon length index (Figure 1B, middle graphs). The body mass of NHERF1+/+ and NHERF1−/− mice was equivalent at 6 weeks of age for both genders...
Furthermore, we show that POT-1 forms a telomeric complex with TEBP-1 and TEBP-2, which bridges TEBP-1/-2 with POT-2/MRT-1. These results provide insights into the composition and organization of a telomeric protein complex in C. elegans....
We found a negative correlation betweenCEBPAexpression and DDIT3 levels in AML cells. After knockdown ofCEBPA, DDIT3 expression was upregulated, resulting in increased apoptotic rate of AML cells induced by ER stress.Cebpaknockdown in mouse 32Dcl3 cells also led to impaired cell viability due to...
The intensity and percentage of cells that reacted with EBP1 antibodies were significantly higher in cases with tubular pattern than those with solid pattern (P<0.0001). We also found adenoid cystic carcinoma with local lymphatic metastasis had significantly lower EBP1 expression than ACC with no ...
into the pathological inclusions in the brain, we conducted the immuno-EM (electron microscopy) analysis and found that AD fecal inoculation triggered both mouse Aβ and Tau accumulation (arrow) in WT mouse brain, and the immuno-activities were profoundly augmented in C/EBPβ transgenic mice (...
We found a heterogeneous expression pattern of the inhibitory form (LIP) in untransfected MM cells. Certain myeloma cells such as INA-6 show no expression of LIP and other cell lines such as MM.1S expressed LIP only after stimulation with IL-1β (supplemental Figure 1, available on the ...
C/EBPα is a transcription factor essential for terminal differentiation of several cell types. It has not known if C/EBPα protein is expressed and functions in the prostate gland. The presence of C/EBPα in normal and cancerous prostate epithelium was
(Fig.1a). The pattern of Pgp expression was in accord with the IC50to doxorubicin of each cell line (Additional file1). Either untreated or doxorubicin-treated cells expressed C/EBP-β LAP. C/EBP-β LIP was induced by doxorubicin in epithelial MCF10A cells and in Pgp-negative breast ...
Cells were washed once in ice-cold phosphate-buffered saline (PBS) and then treated with 2.7 μmol/L DFP (diisopropyl fluorophosphate; Calbiochem, La Jolla, CA) for 10 minutes on ice, then washed 3 times in ice-cold PBS and lysed in Triton buffer (20 mmol/L TrisHCl, pH 8.0, 150 ...
The whole DNA base sequence of the C/EBP2 gene as found in the above manner is as shown by SEQ ID NO:1. The gene according to the invention can also be isolated directly from the clone containing the gene of the invention as isolated in the same manner as above. The gene accordin...